Incidence and factors associated with seroconversion to hepatitis C virus seropositivity amongst patients on maintenance hemodialysis, douala-cameroon

Abstract EN

Hepatitis C virus (HCV) infection one of the most common blood-borne infections is endemic in Cameroon and a serious problem in hemodialysis (HD).

We aimed to determine the annual incidence and factors associated with seroconversion to hepatitis C positivity amongst patients on maintenance HD after an exposition of two years in a center with a high prevalence of hepatitis C (20.6%) and where no isolation policy is practiced.

This was a retrospective cohort study carried out in January 2015 in the HD unit of Douala General Hospital in Cameroon including 71 patients on maintenance HD who tested negative for HCV in January 2013.

Sociodemographic characteristics and clinical data were recorded, while for each patient 10 mL of blood was collected and patients retested for HCV using a fourth-generation ELISA test (BIOREXR BXEO781A).

Fisher’s exact test was used for dichotomous variables and using Mann Whitney’s test for quantitative variables.

Statistical significance was set at P <0.05.

Mean age was 47 ± 13 years with 60.6% male.

Blood transfusion was the main means for anemia management (85.9%) with a median number of blood units received of 5 (1–44).

Facility HCV prevalence was 19.3% in January 2015.

Five out of the 71 patients developed anti-HCV antibodies giving us a seroconversion rate of 7.1% and an incidence of 3.6/100 patient years.

There was no significant association between age (P = 0.4), number of blood units received (P = 0.8) origin of blood units (P = 0.8), scarifications (P = 0.09) and seroconversion.

After two years of exposure seroconversion to HCV positivity was 7.1% in our center with no associated factors.

In a setting with high prevalence of HCV, isolation of positive patient may help to reduce the rate of transmission.