Synthesis and antimicrobial evaluation of some new heterocyclic compounds from thienopyridines and thienopyrimidine derivatives

Abstract EN

4-aryl-3-cyano-5-ethoxycarbonyl-6-methyl pyridine-2-(1H)-thiones 1a,b were prepared and reacted with chloroacetonitrile to furnish 3-amino-4-aryl-2-carbamoyl-5-ethoxycarbonyl-6- methyl thieno[2,3-b]pyridine derivative 3a,b.

The reaction of 3a with a variety of reagent namely, ethylenediamine, sodium azide, tri ethylorthoformate, 4-chlorobenzaldehyde, carbondisulfide and sodium nitrous acid have been carried out and their products were identified .

Most of these products were subjected to further reaction to obtain heterocyclic compounds.

The all synthesized derivatives displayed good Antimicrobial activities against some species of bacteria as ( E.colie, P.seudemones and S.aurous) and some species of fungal as (Aspergillus, Pencillium and Clado)