Resveratrol treatment inhibits acute pharyngitis in the mice model through inhibition of PGE2COX-2 expression
Joint Authors
Source
Saudi Journal of Biological Sciences
Issue
Vol. 25, Issue 7 (30 Nov. 2018), pp.1468-1472, 5 p.
Publisher
Publication Date
2018-11-30
Country of Publication
Saudi Arabia
No. of Pages
5
Main Subjects
Topics
Abstract EN
The aim of the present study was to investigate the effect of resveratrol on acute pharyngitis in the mice models induced by xylene and carrageenan treatment.
The mice treated with various doses of resveratrol (5, 10, 15, 20 and 30 mg/kg) showed inhibition of edema in a dose dependent manner.
The edema formation was reduced by 67% in the mice treated with 20 mg/kg of resveratrol compared to those in the control group.
A significant (P < 0.02) reduction of paw swelling was observed in the mice treated with 20 mg/kg dose of resveratrol compared to the control group.
The inhibition of paw swelling in mice was also caused by votalin by the extent of reduction was significantly (P < 0.02) lower compared to the resveratrol treatment.
In the mice model of paw swelling, treatment with 20 mg/kg doses of resveratrol significantly (P < 0.02) reduced the expression of PGE2 compared to the control group.
On the other hand, resveratrol played a vital role in the inhibition of carrageenan induced increase in the expression of COX-2 in mice.
The inhibition in the COX-2 expression by 20 mg/kg doses of resveratrol was significantly higher compared to the known drug, votalin.
Thus the current study revealed that resveratrol treatment inhibits acute pharyngitis in the mice model through inhibition of PGE2/COX-2 expression.
Thus resveratrol can be used for the treatment of acute pharyngitis.
American Psychological Association (APA)
Yu, Zhaoyan& Xu, Wei& Wang, Haibo. 2018. Resveratrol treatment inhibits acute pharyngitis in the mice model through inhibition of PGE2COX-2 expression. Saudi Journal of Biological Sciences،Vol. 25, no. 7, pp.1468-1472.
https://search.emarefa.net/detail/BIM-897078
Modern Language Association (MLA)
Yu, Zhaoyan…[et al.]. Resveratrol treatment inhibits acute pharyngitis in the mice model through inhibition of PGE2COX-2 expression. Saudi Journal of Biological Sciences Vol. 25, no. 7 (Nov. 2018), pp.1468-1472.
https://search.emarefa.net/detail/BIM-897078
American Medical Association (AMA)
Yu, Zhaoyan& Xu, Wei& Wang, Haibo. Resveratrol treatment inhibits acute pharyngitis in the mice model through inhibition of PGE2COX-2 expression. Saudi Journal of Biological Sciences. 2018. Vol. 25, no. 7, pp.1468-1472.
https://search.emarefa.net/detail/BIM-897078
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 1471-1472
Record ID
BIM-897078