Bladder cancer cell viability inhibition and apoptosis induction by baicalein through targeting the expression of anti-apoptotic genes
Joint Authors
Liu, Kun
Yang, Libo
Zhang, Guoying
Yang, Yong
Source
Saudi Journal of Biological Sciences
Issue
Vol. 25, Issue 7 (30 Nov. 2018), pp.1478-1482, 5 p.
Publisher
Publication Date
2018-11-30
Country of Publication
Saudi Arabia
No. of Pages
5
Main Subjects
Topics
Abstract EN
The study was aimed to investigate the effect of baicalein, a flavonoid molecule isolated from the plant Oroxylum indicum on bladder cancer cell viability.
The results revealed that baicalein treatment of T24 and 253J bladder cancer cells targeted the expression of mRNA and proteins corresponding to the antiapoptotic genes.
RT-PCR assay showed that anti-apoptotic genes were markedly over-expressed in the bladder cancer cells.
Exposure of the bladder cancer cells to baicalein at 5 mg/mL doses for 72 h led to reduction in the expression of mRNA levels of antiapoptotic genes.
In T24 cells, the levels of BCL2, BclxL, XIAP and surviving was reduced by 65, 69, 58 and 72%, respectively.
In T24 and 253J cells exposure to baicalein for 72 h resulted respectively in 39 and 46% reduction in cell viability.
Baicalein treatment also induced apoptosis in the bladder cancer cells.
In T24 and 253J cells baicalein treatment at 5 mg/ mL for 72 h induced apoptosis in 79 and 86% cells respectively.
Thus, baicalein mediated reduction in antiapoptotic gene expression inhibits viability and induces apoptosis in bladder cancer cells.
Therefore, baicalein is of therapeutic importance for the development of bladder cancer treatment strategy.
American Psychological Association (APA)
Yang, Yong& Liu, Kun& Yang, Libo& Zhang, Guoying. 2018. Bladder cancer cell viability inhibition and apoptosis induction by baicalein through targeting the expression of anti-apoptotic genes. Saudi Journal of Biological Sciences،Vol. 25, no. 7, pp.1478-1482.
https://search.emarefa.net/detail/BIM-897157
Modern Language Association (MLA)
Yang, Yong…[et al.]. Bladder cancer cell viability inhibition and apoptosis induction by baicalein through targeting the expression of anti-apoptotic genes. Saudi Journal of Biological Sciences Vol. 25, no. 7 (Nov. 2018), pp.1478-1482.
https://search.emarefa.net/detail/BIM-897157
American Medical Association (AMA)
Yang, Yong& Liu, Kun& Yang, Libo& Zhang, Guoying. Bladder cancer cell viability inhibition and apoptosis induction by baicalein through targeting the expression of anti-apoptotic genes. Saudi Journal of Biological Sciences. 2018. Vol. 25, no. 7, pp.1478-1482.
https://search.emarefa.net/detail/BIM-897157
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 1482
Record ID
BIM-897157