Effect of artemisinin on proliferation and apoptosis-related protein expression in vivo and in vitro

Abstract EN

Artemisinin is the first-line drugs for the treatment of malaria.

In recent years, a large number of reports showed that artemisinin exhibit anti-tumor activity.

In this study, we used C6 glioma cells and rat C6 brain-glioma model to study anti-tumor activity of artemisinin in vivo and in vitro.

We found that artemisinin inhibited the proliferation in C6 cells and induced cell cycle arrest and a caspase-3-dependent cell apoptosis.

It also inhibited the growth of C6 brain-glioma in vivo and enhanced living state of rat brain-glioma model.

These results suggested that artemisinin had significant anti-tumor activities on C6 cells both in vitro and in vivo.

Artemisinin might be exploited as a promising clinical anti-cancer drug in future.