Effect of artemisinin on proliferation and apoptosis-related protein expression in vivo and in vitro
Joint Authors
Zhang, Lei
Chen, Jiajun
Hao, Miao
Source
Saudi Journal of Biological Sciences
Issue
Vol. 25, Issue 7 (30 Nov. 2018), pp.1488-1493, 6 p.
Publisher
Publication Date
2018-11-30
Country of Publication
Saudi Arabia
No. of Pages
6
Main Subjects
Topics
Abstract EN
Artemisinin is the first-line drugs for the treatment of malaria.
In recent years, a large number of reports showed that artemisinin exhibit anti-tumor activity.
In this study, we used C6 glioma cells and rat C6 brain-glioma model to study anti-tumor activity of artemisinin in vivo and in vitro.
We found that artemisinin inhibited the proliferation in C6 cells and induced cell cycle arrest and a caspase-3-dependent cell apoptosis.
It also inhibited the growth of C6 brain-glioma in vivo and enhanced living state of rat brain-glioma model.
These results suggested that artemisinin had significant anti-tumor activities on C6 cells both in vitro and in vivo.
Artemisinin might be exploited as a promising clinical anti-cancer drug in future.
American Psychological Association (APA)
Chen, Jiajun& Zhang, Lei& Hao, Miao. 2018. Effect of artemisinin on proliferation and apoptosis-related protein expression in vivo and in vitro. Saudi Journal of Biological Sciences،Vol. 25, no. 7, pp.1488-1493.
https://search.emarefa.net/detail/BIM-897171
Modern Language Association (MLA)
Chen, Jiajun…[et al.]. Effect of artemisinin on proliferation and apoptosis-related protein expression in vivo and in vitro. Saudi Journal of Biological Sciences Vol. 25, no. 7 (Nov. 2018), pp.1488-1493.
https://search.emarefa.net/detail/BIM-897171
American Medical Association (AMA)
Chen, Jiajun& Zhang, Lei& Hao, Miao. Effect of artemisinin on proliferation and apoptosis-related protein expression in vivo and in vitro. Saudi Journal of Biological Sciences. 2018. Vol. 25, no. 7, pp.1488-1493.
https://search.emarefa.net/detail/BIM-897171
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 1493
Record ID
BIM-897171