L-arginine and tetrahydrobiopterin modulate endothelin-1A receptor activity in isolated rat aorta
Joint Authors
Khudhur, Zhikal O.
Mawlud, Ismail M.
Source
ZANCO Journal of Pure and Applied Sciences
Issue
Vol. 31, Issue 2 (30 Apr. 2019), pp.101-108, 8 p.
Publisher
Salahaddin University-Erbil Department of Scientific Publications
Publication Date
2019-04-30
Country of Publication
Iraq
No. of Pages
8
Main Subjects
Topics
Abstract EN
Endothelin-1 (ET-1), is a potent endogenous vasoconstrictor secreted by endothelial cells.
It acts as the natural counterpart of the vasodilator effect of nitric oxide (NO).
ET-1 exert it is the vasoconstrictor activity through two types of receptors, ET-1A and ET-1B receptors that are located on vascular smooth muscle cells (VSMCs).
The present study was designed to evaluate the effect of L-arginine (LA), tetrahydrobiopterin (BH4), and their combination on ET-1A receptor activity in rat aortic rings.
The study involved pre-incubation of rat aortic rings with LA, BH4, and their combination.
Then, the vascular response to a cumulative dose of the ET-1A receptor antagonist (BQ-123) and in the second set of experiment cumulative doses of Acetylcholine (ACh) were applied to each group.
BQ-123 potency increased after LA pre-incubation, but LA and BH4 in combination significantly potentiated BQ-123 potency and maximum response.
In the second set of experiment, ACh potency does not change, while ACh efficacy markedly increased during pre-incubation of LA, BH4, and their combination.
In conclusion, LA and BH4 may offer some pharmacological tools to modulate the ET-1A receptor activity and treat cardiovascular disease beyond pulmonary arterial hypertension.
American Psychological Association (APA)
Khudhur, Zhikal O.& Mawlud, Ismail M.. 2019. L-arginine and tetrahydrobiopterin modulate endothelin-1A receptor activity in isolated rat aorta. ZANCO Journal of Pure and Applied Sciences،Vol. 31, no. 2, pp.101-108.
https://search.emarefa.net/detail/BIM-897279
Modern Language Association (MLA)
Khudhur, Zhikal O.& Mawlud, Ismail M.. L-arginine and tetrahydrobiopterin modulate endothelin-1A receptor activity in isolated rat aorta. ZANCO Journal of Pure and Applied Sciences Vol. 31, no. 2 (2019), pp.101-108.
https://search.emarefa.net/detail/BIM-897279
American Medical Association (AMA)
Khudhur, Zhikal O.& Mawlud, Ismail M.. L-arginine and tetrahydrobiopterin modulate endothelin-1A receptor activity in isolated rat aorta. ZANCO Journal of Pure and Applied Sciences. 2019. Vol. 31, no. 2, pp.101-108.
https://search.emarefa.net/detail/BIM-897279
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 106-107
Record ID
BIM-897279