Effects of green coffee extract supplementation on oxidative stress, systemic and vascular inflammation in patients with metabolic syndrome : a randomized clinical trial
Joint Authors
Nikpayam, Omid
Rushan, Hanieh
Sohrab, Golbon
Sedaghat, Meghdad
Source
Iranian Red Crescent Medical Journal
Issue
Vol. 20, Issue 6 (30 Jun. 2018), pp.1-10, 10 p.
Publisher
Publication Date
2018-06-30
Country of Publication
United Arab Emirates
No. of Pages
10
Main Subjects
Abstract EN
Background: Metabolic syndrome (Mets) is accompanied by oxidative stress and low-grade inflammation.
Green coffee is rich in polyphenols called chlorogenic acids (CGA), which possess anti-inflammatory and anti-oxidative characteristics.
Objectives: The aim of this study was to evaluate the effects of green coffee extract (GCE) on the oxidative stress as well as the systemic and vascular inflammation in patients having Mets.
Methods: This randomized clinical trial was conducted in 2016 in Iran.
Forty-three individuals (21 in the intervention and 22 in the control group) with Mets were randomly assigned to take 400 mg GCE supplements twice a day in the intervention group or placebo capsules in the control group for 8 -weeks.
The serum levels of intercellular adhesion molecule-1 (ICAM-1), interleukin-6 (IL-6), high sensitivity C-reactive protein (hs-CRP), and malondialdehyde (MDA) were evaluated at the beginning and 8 -weeks after the intervention.
Results: No significant discrepancy was observed regarding serum levels of IL-6, MDA, hs-CRP, and ICAM-1 between the intervention and control group at the beginning and the end of the trial.
After eight weeks of intervention, the mean changes of IL6 in the treatment and the placebo group were respectively (-0.73 ± 2.65 VS 1.70 ± 10.51 Pg/mL, P value = 0.3), hs-CRP (-0.28 ± 3.12 VS -0.08 ± 4.15mg/L, P value = 0.86), MDA (0.44 ± 1.68 VS 0.32 ± 2.28 μmol/L, P value = 0.84), and ICAM-1 (-0.05 ± 0.45 VS 0.02 ± 0.45ng/mL, P value = 0.54).
Conclusions: In this trial, the green coffee extract (GCE) administration did not affect oxidative stress, systemic, and vascular inflammation in subjects with metabolic syndrome.
American Psychological Association (APA)
Nikpayam, Omid& Rushan, Hanieh& Sohrab, Golbon& Sedaghat, Meghdad. 2018. Effects of green coffee extract supplementation on oxidative stress, systemic and vascular inflammation in patients with metabolic syndrome : a randomized clinical trial. Iranian Red Crescent Medical Journal،Vol. 20, no. 6, pp.1-10.
https://search.emarefa.net/detail/BIM-897334
Modern Language Association (MLA)
Nikpayam, Omid…[et al.]. Effects of green coffee extract supplementation on oxidative stress, systemic and vascular inflammation in patients with metabolic syndrome : a randomized clinical trial. Iranian Red Crescent Medical Journal Vol. 20, no. 6 (Jun. 2018), pp.1-10.
https://search.emarefa.net/detail/BIM-897334
American Medical Association (AMA)
Nikpayam, Omid& Rushan, Hanieh& Sohrab, Golbon& Sedaghat, Meghdad. Effects of green coffee extract supplementation on oxidative stress, systemic and vascular inflammation in patients with metabolic syndrome : a randomized clinical trial. Iranian Red Crescent Medical Journal. 2018. Vol. 20, no. 6, pp.1-10.
https://search.emarefa.net/detail/BIM-897334
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 9-10
Record ID
BIM-897334