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Protective effect of tea grape extract on cisplatin-induced muscle atrophy : a morphological study
Joint Authors
Balik, Mehmet Sabri
Mercantepe, Tolga
Yilmaz, Adnan
Balik, Gulsah
Topcu, Atilla
Yazici, Zihni
Tumkaya, Levent
Source
Iranian Red Crescent Medical Journal
Issue
Vol. 20, Issue 9 (30 Sep. 2018), pp.1-7, 7 p.
Publisher
Publication Date
2018-09-30
Country of Publication
United Arab Emirates
No. of Pages
7
Main Subjects
Abstract EN
Background: Even though Cisplatin (Cis) is known to be organotoxic, it is used in neoplastic chemotherapy.
In skeletal muscles, the toxic effect manifests as atrophy.
Objectives: The tea grape extract (TGE) is a sort of whortleberry that has various physiological effects including prevention of chemically induced cellular insults.
Therefore, we examined if the TGE has a protective effect against the Cis induced skeletal muscle atrophy.
Methods: Female Sprague-Dawley rats were used in this animal experimental study.
Rats were allocated into different study groups, each with eight members.
The groups comprised control, solvent control, 200 mg TGE, Cis, Cis + 100 mg TGE, and Cis + 200 mg TGE.
Results: The mean fiber area of the skeletal muscle (MFASM) decreased significantly in the Cis group in comparison to the control group (P = 0.01).
MFASM showed similarities between the Cis + TGE 200 and control groups (P > 0.05, P = 0.418).
Similarities were also observed for MFASM between the Cis + 100 mg TGE and Cis + 200 mg TGE groups (P > 0.05, P = 0.891).
The mean serum calcium level in the Cis group (10.26 ± 0.29) was significantly higher in TGE 100 (9.13 ± 0.11) and TGE 200 groups (9.21 ± 0.13).
Conclusions: It is concluded that the tea grape extract has a protective effect on Cis-induced toxicity of the skeletal muscles.
American Psychological Association (APA)
Balik, Mehmet Sabri& Tumkaya, Levent& Mercantepe, Tolga& Yilmaz, Adnan& Balik, Gulsah& Topcu, Atilla…[et al.]. 2018. Protective effect of tea grape extract on cisplatin-induced muscle atrophy : a morphological study. Iranian Red Crescent Medical Journal،Vol. 20, no. 9, pp.1-7.
https://search.emarefa.net/detail/BIM-897354
Modern Language Association (MLA)
Balik, Mehmet Sabri…[et al.]. Protective effect of tea grape extract on cisplatin-induced muscle atrophy : a morphological study. Iranian Red Crescent Medical Journal Vol. 20, no. 9 (Sep. 2018), pp.1-7.
https://search.emarefa.net/detail/BIM-897354
American Medical Association (AMA)
Balik, Mehmet Sabri& Tumkaya, Levent& Mercantepe, Tolga& Yilmaz, Adnan& Balik, Gulsah& Topcu, Atilla…[et al.]. Protective effect of tea grape extract on cisplatin-induced muscle atrophy : a morphological study. Iranian Red Crescent Medical Journal. 2018. Vol. 20, no. 9, pp.1-7.
https://search.emarefa.net/detail/BIM-897354
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 6-7
Record ID
BIM-897354