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Spectrophotometric determination of chlordiazepoxide in pharmaceutical formulations via oxidative coupling reaction with phenothiazine
Other Title(s)
التقدير الطيفي للكلورديازيبوكسيد في الأشكال الصيدلانية بواسطة تفاعل الازدواج التأكسدي مع الفينوثيازين
Joint Authors
Ahmad, Maryam Jamal
Abd Allah, Hind Hadi
Source
Iraqi Journal of Pharmaceutical Sciences
Issue
Vol. 27, Issue 2 (31 Dec. 2018), pp.7-11, 5 p.
Publisher
University of Baghdad College of Pharmacy
Publication Date
2018-12-31
Country of Publication
Iraq
No. of Pages
5
Main Subjects
Topics
Abstract EN
A sensitive, precise and reliable indirect spectrophotometric method for the determination of chlordiazepoxide (CDE) in pure and pharmaceutical dosage forms is described.
The method is based on oxidative coupling reaction between amino group resulting from acidic decomposition of CDE with phenothiazine in the presence of sodium periodate to produce an intense green soluble dye that is stable and shows a maximum absorption at 602 nm.
The calibration plot indicates that Beer’s law is obeyed over the concentration range of 0.1−50 μg/mL, with a molar absorptivity of 1×104 L/mol cm and correlation coefficient of 0.9994.All the conditions that affecting on the stability and sensitivity of the formed product were studied and optimized and the suggested method was effectively applied for the determination of CDE in commercial dosage forms.
American Psychological Association (APA)
Ahmad, Maryam Jamal& Abd Allah, Hind Hadi. 2018. Spectrophotometric determination of chlordiazepoxide in pharmaceutical formulations via oxidative coupling reaction with phenothiazine. Iraqi Journal of Pharmaceutical Sciences،Vol. 27, no. 2, pp.7-11.
https://search.emarefa.net/detail/BIM-897596
Modern Language Association (MLA)
Ahmad, Maryam Jamal& Abd Allah, Hind Hadi. Spectrophotometric determination of chlordiazepoxide in pharmaceutical formulations via oxidative coupling reaction with phenothiazine. Iraqi Journal of Pharmaceutical Sciences Vol. 27, no. 2 (2018), pp.7-11.
https://search.emarefa.net/detail/BIM-897596
American Medical Association (AMA)
Ahmad, Maryam Jamal& Abd Allah, Hind Hadi. Spectrophotometric determination of chlordiazepoxide in pharmaceutical formulations via oxidative coupling reaction with phenothiazine. Iraqi Journal of Pharmaceutical Sciences. 2018. Vol. 27, no. 2, pp.7-11.
https://search.emarefa.net/detail/BIM-897596
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 13-14
Record ID
BIM-897596