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Effects of vitamin e and q10 supplementation against doxorubicin-induced neurotoxicity in rats
Other Title(s)
تأثير فيتامين (ه) و مكمل Q10 على سمية الدماغ المستحدثة بواسطة الدوكسوروبيسين في الجرذان
Joint Authors
al-Kim, Manal Abd al-Khaliq
al-Shawi, Nada Naji
Source
Iraqi Journal of Pharmaceutical Sciences
Issue
Vol. 27, Issue 2 (31 Dec. 2018), pp.24-31, 8 p.
Publisher
University of Baghdad College of Pharmacy
Publication Date
2018-12-31
Country of Publication
Iraq
No. of Pages
8
Main Subjects
Topics
Abstract EN
Doxorubicin (DOX) is a chemotherapeutic agent; it is widely used in human malignancies.
Its long-term use can cause neurobiological side-effects.
Vitamin E and Coenzyme Q10 may possess neuroprotective effects.
This work was designed to investigate the effect of vitamin E and the coenzyme Q10 (CoQ10) supplementation on neurotoxicity induced by doxorubicin (DOX) in rats.
Forty nine adult rats of both sexes were used in this study; the animals were randomly enrolled into seven groups of 7 rats each.
Group I: negative control (rats administered corn oil); Group II: Vitamin E at a dose of 100mg/kg/d for 3 weeks ; Group III: CoQ10 at a dose of 50 mg/kg/d for 3 weeks; Group IV: positive control (Doxorubicin 2.5 mg/kg) every other day for 2 weeks; Group V: vitamin E at a dose of 100mg/kg/d for 3 weeks administered prior to Doxorubicin at dose 2.5 mg/kg every other day for 2 weeks; Group VI: CoQ10 at a dose of 50 mg/kg/d for 3 weeks administered prior to Doxorubicin at dose 2.5 mg/kg every other day for 2 weeks.
Group VII: CoQ10 (50mg/kg/day), Vitamin E (100mg/kg) for 3 weeks administered prior to Doxorubicin at dose 2.5 mg/kg every other day for 2 weeks.
On day twenty two of the study, brain of each animal was excised and part of it to be utilized to prepare homogenate for estimation interleukin-1 beta (IL-1β), and interleukin-10 (IL-10); the other part of brain was used for histological examination.
Vitamin E and CoQ10 significantly (P<0.05) decreased IL-1beta, and only combination vitamin E and CoQ10 significantly (P<0.05) increased IL-10 and there was an improvement in the histopathological lesions of the brain in group V, group VI and group VII compared to group IV.
In conclusion both Vitamin E and CoQ10 may have protective effect against DOX-induced neurotoxicity in rats.
American Psychological Association (APA)
al-Kim, Manal Abd al-Khaliq& al-Shawi, Nada Naji. 2018. Effects of vitamin e and q10 supplementation against doxorubicin-induced neurotoxicity in rats. Iraqi Journal of Pharmaceutical Sciences،Vol. 27, no. 2, pp.24-31.
https://search.emarefa.net/detail/BIM-897603
Modern Language Association (MLA)
al-Kim, Manal Abd al-Khaliq& al-Shawi, Nada Naji. Effects of vitamin e and q10 supplementation against doxorubicin-induced neurotoxicity in rats. Iraqi Journal of Pharmaceutical Sciences Vol. 27, no. 2 (2018), pp.24-31.
https://search.emarefa.net/detail/BIM-897603
American Medical Association (AMA)
al-Kim, Manal Abd al-Khaliq& al-Shawi, Nada Naji. Effects of vitamin e and q10 supplementation against doxorubicin-induced neurotoxicity in rats. Iraqi Journal of Pharmaceutical Sciences. 2018. Vol. 27, no. 2, pp.24-31.
https://search.emarefa.net/detail/BIM-897603
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 30-31
Record ID
BIM-897603