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Impact of osteocalcin level on vascular calcification in type 2 diabetics in relation to fibroblast growth factor-23(FGF-23)
Other Title(s)
تأثير مستوى الأوستيوكالسين على تكلس الأوعية الدموية في مرضى السكري من النوع الثاني و المتعلق بعامل نمو الأرومة الليفية-23 (اف جي اف-23)
Joint Authors
Ali, Inas Abd al-Muhsin
Ali, Shadha Husayn
Source
Iraqi Journal of Pharmaceutical Sciences
Issue
Vol. 27, Issue 2 (31 Dec. 2018), pp.42-54, 13 p.
Publisher
University of Baghdad College of Pharmacy
Publication Date
2018-12-31
Country of Publication
Iraq
No. of Pages
13
Main Subjects
Topics
Abstract EN
The present study aimed to assess the potential impact of serum concentration of undercarboxylated osteocalcin (the active form of osteocalcin) and fibroblast growth factor-23 on the incidence of cardiovascular diseases in type 2 diabetics with carotid artery calcification and the possible association with metabolic changes in relation to glucose and minerals homeostasis.
This study included 52 men with carotid artery calcification type 2 diabetes mellitus.
These patients were categorized; as follows: group A includes 30 patients who had cardiovascular disease and group B includes 22 patients who had no cardiovascular disease.
These groups were compared with 25 apparently healthy control (Group C).
It has been shown that fasting serum glucose, HbA1c, homeostatic model assessment of insulin resistance and undercarboxylated osteocalcin values were significantly different in group A and B as compared with control.
Also, undercarboxylated osteocalcin was negatively correlated with fasting serum glucose and HbA1c in group A and B.
Furthermore, mean serum fibroblast growth factor level was significantly different among the three studied groups, with highest levels in group A.
In type 2 diabetic patients with normal kidney function and carotid artery calcification, fibroblast growth factor-23 is associated with cardiovascular disease while undercarboxylated osteocalcin does not.
American Psychological Association (APA)
Ali, Inas Abd al-Muhsin& Ali, Shadha Husayn. 2018. Impact of osteocalcin level on vascular calcification in type 2 diabetics in relation to fibroblast growth factor-23(FGF-23). Iraqi Journal of Pharmaceutical Sciences،Vol. 27, no. 2, pp.42-54.
https://search.emarefa.net/detail/BIM-897611
Modern Language Association (MLA)
Ali, Inas Abd al-Muhsin& Ali, Shadha Husayn. Impact of osteocalcin level on vascular calcification in type 2 diabetics in relation to fibroblast growth factor-23(FGF-23). Iraqi Journal of Pharmaceutical Sciences Vol. 27, no. 2 (2018), pp.42-54.
https://search.emarefa.net/detail/BIM-897611
American Medical Association (AMA)
Ali, Inas Abd al-Muhsin& Ali, Shadha Husayn. Impact of osteocalcin level on vascular calcification in type 2 diabetics in relation to fibroblast growth factor-23(FGF-23). Iraqi Journal of Pharmaceutical Sciences. 2018. Vol. 27, no. 2, pp.42-54.
https://search.emarefa.net/detail/BIM-897611
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 50-54
Record ID
BIM-897611