Clinical outcomes and electrolyte balance factors in complex cardiac operations in adults ; del nido ® versus custodiol ® cardioplegia solutions : a randomized controlled clinical trial
Joint Authors
Mehrabanian, Muhammad Jawad
Fayruz Abadi, Mahdi Dehghani
Tafti, Sayyid Husayn Ahmadi
Nia, Sayyid Khalil Forouzan
Murtazian, Maysam
Dawani, Sam Zeraatian Nijad
Sultaninia, Hasan
Ghiasi, Abbas
Gorjipour, Farhad
Gurabi, Armita Mahdi
Najafi, Atabak
Source
Iranian Red Crescent Medical Journal
Issue
Vol. 20, Issue 4 (30 Apr. 2018), pp.1-8, 8 p.
Publisher
Publication Date
2018-04-30
Country of Publication
United Arab Emirates
No. of Pages
8
Main Subjects
Abstract EN
Background: Cardioplegia is used for protection of myocardium during cardiac operations.
Del Nido® (DN) and Custodiol® cardioplegia (CC) solutions are used for prolonged protection of the myocardium during cardiopulmonary bypass (CPB).
Custodiol® cardioplegia solution is gaining popularity for myocardial protection during cardiopulmonary bypass.
Objectives: This study aimed to compare the effects of Custodiol® with another cardioplegia solution, Del Nido®, on myocardial protection during cardiopulmonary bypass.
Methods: In a randomized controlled clinical trial, forty patients were randomly allocated to DelNido® and Custodiol® (CC) groups.
Patients in both groups received a standard anesthesia protocol.
For cardioplegia, in the DN group, the Del Nido® solution was administered every 90 minutes by the antegrade route.
In the CC, group, the Custodiol® solution was administered in the same way at the beginning of the cardioplegia.
Demographic information, blood chemistry parameters and other related perioperative and postoperative clinical indices were recorded.
Results: Frequency of female patients was 14/21 (66.66 %) in the DN and 12/19 (63.15 %) in the CC group (P = 0.816), age was 57.1412.48 years versus 59.4711.96 years (P = 0.551), weight was 70.959.56 kilograms versus 69.637.64 kilograms (P = 0.635), CPB time was 103.1923.43 minutes versus 97.3616.7 minutes (P = 0.376), and cross-clamp time was 73.7619.66 minutes versus 83.9516.14 minutes (P = 0.083).
Blood chemistry and blood gas analysis revealed a similar trend between the two groups in these parameters (P > 0.05) except for higher sodium levels after cardioplegia (P = 0.016) and end of CPB (P = 0.002), potassium levels after cardioplegia (P = 0.029), and bicarbonate anions at the end of bypass (P = 0.03) in the Custodiol® group.
Conclusions: In conclusion, CC and DN offer effective myocardial protection during cardiopulmonary bypass.
It is recommended to restrict the use of CC in patients susceptible to electrolyte disturbances.
American Psychological Association (APA)
Mehrabanian, Muhammad Jawad& Fayruz Abadi, Mahdi Dehghani& Tafti, Sayyid Husayn Ahmadi& Nia, Sayyid Khalil Forouzan& Najafi, Atabak& Murtazian, Maysam…[et al.]. 2018. Clinical outcomes and electrolyte balance factors in complex cardiac operations in adults ; del nido ® versus custodiol ® cardioplegia solutions : a randomized controlled clinical trial. Iranian Red Crescent Medical Journal،Vol. 20, no. 4, pp.1-8.
https://search.emarefa.net/detail/BIM-897771
Modern Language Association (MLA)
Mehrabanian, Muhammad Jawad…[et al.]. Clinical outcomes and electrolyte balance factors in complex cardiac operations in adults ; del nido ® versus custodiol ® cardioplegia solutions : a randomized controlled clinical trial. Iranian Red Crescent Medical Journal Vol. 20, no. 4 (Apr. 2018), pp.1-8.
https://search.emarefa.net/detail/BIM-897771
American Medical Association (AMA)
Mehrabanian, Muhammad Jawad& Fayruz Abadi, Mahdi Dehghani& Tafti, Sayyid Husayn Ahmadi& Nia, Sayyid Khalil Forouzan& Najafi, Atabak& Murtazian, Maysam…[et al.]. Clinical outcomes and electrolyte balance factors in complex cardiac operations in adults ; del nido ® versus custodiol ® cardioplegia solutions : a randomized controlled clinical trial. Iranian Red Crescent Medical Journal. 2018. Vol. 20, no. 4, pp.1-8.
https://search.emarefa.net/detail/BIM-897771
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 7-8
Record ID
BIM-897771