Synthesis, antibacterial and antifungal activities for novel derivatives of2,2'-(((1-benzylbenzoimidazol-2-yl) methyl) azanediyl) bis (ethan-1-ol)
Joint Authors
Shakir, Raid Mustafa
Jar Allah, Aziz Latif
Ali, Khalid Fahd
Suud, Shayma Abd
Source
Ibn al-Haitham Journal for Pure and Applied Science
Issue
Vol. 32, Issue 1 (30 Apr. 2019), pp.57-79, 23 p.
Publisher
University of Baghdad College of Education for Pure Science / Ibn al-Haitham
Publication Date
2019-04-30
Country of Publication
Iraq
No. of Pages
23
Main Subjects
Topics
- Physiological effects
- Biosynthesis
- Chemicals
- Antibacterial agents
- Antifungal agents
- Derivatives(Chemicals)
Abstract EN
The compound 2,2'-(((1h-benzo(d) imidazol-2-yl)methyl)azanediyl)bis(ethan-1-ol) was reacted with benzyl bromide to afford compound (1) which used as row material to prepare a series of compounds through condensation reaction, the starting compound were reacted with tosyl chloride to protect the oh group to afford compound 2, then reacted benzyl bromide to produce compound (2), then the compound (2) treated with three compounds (2- mercaptobenzthiazole, 2-mercaptobenimidazol and 2-chloromethyl benzimidazole) to form compounds 3a, b, 4a,b and 5a,b respectively.
in the another step the click reaction of compound 2, 2'-(((1h-benzo(d)imidazol-2-yl) methyl) azanediyl)bis(ethan-1-ol) with propargyl bromide produce compound 6 which reacted with sodium azide or benzyl azide to afford the compounds 7 and 8.
the synthesized compounds were characterized and measured the physical properties via the ft-ir, hnmr, besides to the chn analysis.
these newly compounds were screened their antibacterial and antifungal activity.
compounds 1, 2a and 8 showed significant antibacterial activity as well these compounds exhibited either low or moderated antifungal activity.
American Psychological Association (APA)
Jar Allah, Aziz Latif& Ali, Khalid Fahd& Shakir, Raid Mustafa& Suud, Shayma Abd. 2019. Synthesis, antibacterial and antifungal activities for novel derivatives of2,2'-(((1-benzylbenzoimidazol-2-yl) methyl) azanediyl) bis (ethan-1-ol). Ibn al-Haitham Journal for Pure and Applied Science،Vol. 32, no. 1, pp.57-79.
https://search.emarefa.net/detail/BIM-898099
Modern Language Association (MLA)
Jar Allah, Aziz Latif…[et al.]. Synthesis, antibacterial and antifungal activities for novel derivatives of2,2'-(((1-benzylbenzoimidazol-2-yl) methyl) azanediyl) bis (ethan-1-ol). Ibn al-Haitham Journal for Pure and Applied Science Vol. 32, no. 1 (2019), pp.57-79.
https://search.emarefa.net/detail/BIM-898099
American Medical Association (AMA)
Jar Allah, Aziz Latif& Ali, Khalid Fahd& Shakir, Raid Mustafa& Suud, Shayma Abd. Synthesis, antibacterial and antifungal activities for novel derivatives of2,2'-(((1-benzylbenzoimidazol-2-yl) methyl) azanediyl) bis (ethan-1-ol). Ibn al-Haitham Journal for Pure and Applied Science. 2019. Vol. 32, no. 1, pp.57-79.
https://search.emarefa.net/detail/BIM-898099
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 77-79
Record ID
BIM-898099