Evaluation of FTO rs9939609 and MC4R rs17782313 polymorphisms as prognostic biomarkers of obesity : a population-based cross-sectional study
Joint Authors
Houshmand, Massoud
Muzaffar Zadah, Mina
Muhammadi, Muhsin
Sadiqi, Suha
Hadi Zadah, Murtada
Talib Zadah, Tayyib
Source
Issue
Vol. 34, Issue 1 (31 Jan. 2019), pp.56-62, 7 p.
Publisher
Publication Date
2019-01-31
Country of Publication
Oman
No. of Pages
7
Main Subjects
Topics
Abstract EN
Objectives : obesity is a significant risk factor for a number of chronic diseases, including diabetes, cardiovascular diseases, and cancer.
obesity usually results from a combination of causes and contributing factors, including genetics and lifestyle choices.
many studies have shown an association of single nucleotide polymorphisms (SNPS) in the fat mass and obesity-associated (FTO) and the melanocortin-4 receptor (mc4r) genes with body mass index (BMI).
therefore, recognizing the main genes and their relevant genetic variants will aid prediction of obesity risk.
the aim of our study was to investigate the frequency of rs9939609 and rs17782313 polymorphisms in FTO and mc4r genes in an Iranian population.
Methods : we enrolled 130 obese patients and 83 healthy weight controls and calculated their BMI.
genomic DNA was extracted from peripheral blood and the frequency of rs9939609 and rs17782313 polymorphisms in FTO and mc4r genes was determined using the tetra-primer amplification refractory mutation system-polymerase chain reaction (arms-pcr).
Results : significant associations were found between FTO rs9939609 and BMI.
where homozygous risk allele carriers (a-a) have significant higher odds ratio (or) of being obese than individuals with normal BMI (or = 6.927, p < 0.005, 95% confidence interval (ci): 3.48–13.78).
no significant correlation between mc4r rs17782313 and obesity were observed when compared to healthy weight individuals.
although subjects with c-c genotype had higher odds of obesity (or = 1.889, p = 0.077, 95% ci: 0.92–3.84).
conclusions : this study shows a relationship between FTO polymorphism and increased BMI, therefore, SNP in the FTO gene influence changes in BMI and can be considered a prognostic marker of obesity risk.
American Psychological Association (APA)
Muzaffar Zadah, Mina& Muhammadi, Muhsin& Sadiqi, Suha& Hadi Zadah, Murtada& Talib Zadah, Tayyib& Houshmand, Massoud. 2019. Evaluation of FTO rs9939609 and MC4R rs17782313 polymorphisms as prognostic biomarkers of obesity : a population-based cross-sectional study. Oman Medical Journal،Vol. 34, no. 1, pp.56-62.
https://search.emarefa.net/detail/BIM-898156
Modern Language Association (MLA)
Muzaffar Zadah, Mina…[et al.]. Evaluation of FTO rs9939609 and MC4R rs17782313 polymorphisms as prognostic biomarkers of obesity : a population-based cross-sectional study. Oman Medical Journal Vol. 34, no. 1 (Jan. 2019), pp.56-62.
https://search.emarefa.net/detail/BIM-898156
American Medical Association (AMA)
Muzaffar Zadah, Mina& Muhammadi, Muhsin& Sadiqi, Suha& Hadi Zadah, Murtada& Talib Zadah, Tayyib& Houshmand, Massoud. Evaluation of FTO rs9939609 and MC4R rs17782313 polymorphisms as prognostic biomarkers of obesity : a population-based cross-sectional study. Oman Medical Journal. 2019. Vol. 34, no. 1, pp.56-62.
https://search.emarefa.net/detail/BIM-898156
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 61-62
Record ID
BIM-898156