The association of C-Reactive Protein (CRP) Gene Polymorphism (+ 1059 G > C) with type 2 diabetes mellitus in the Northwestern population of Iran
Joint Authors
Source
Iranian Red Crescent Medical Journal
Issue
Vol. 20, Issue 11 (30 Nov. 2018), pp.1-6, 6 p.
Publisher
Publication Date
2018-11-30
Country of Publication
United Arab Emirates
No. of Pages
6
Main Subjects
Abstract EN
Background : C-reactive protein (CRP) is an acute-phase protein that serves as an early biomarker for inflammation.
It has been associated with an increased risk of Type 2 Diabetes Mellitus (T2DM).
Objectives : This research investigated the association of +1059 G > C (rs1800947) polymorphism in the CRP gene with T2DM in the northwestern population of Iran.
Methods : In this case-control study, genomic DNA was extracted from human subjects, involving 77 unrelated T2DM patients and 80 unrelated non-diabetic volunteers of a northwestern population of Iran.
The CRP gene was analyzed by genotyping for +1059G > C (rs1800947), allele-specific polymerase chain reaction (AS-PCR).
Results : There were 24 (15.3 %) CC genotypes, 126 (80.2 %) CG genotypes, and seven (4.5 %) GG genotypes.
There was a significant relationship between the CG genotype of CRP +1059 G>C gene polymorphism and T2DM (P value = 0.037, 95 % CI, OR = 2.385).
Conclusions : The CRP was associated with T2DM in this population.
The frequency of the C allele was high in the northwestern population of Iran.
The CG genotype almost doubled the risk of T2DM, which has not been reported in Iran previously.
However, the primary finding of this study needs subsequent validation studies.
American Psychological Association (APA)
Jalili, Ziba& Onsori, Habib. 2018. The association of C-Reactive Protein (CRP) Gene Polymorphism (+ 1059 G > C) with type 2 diabetes mellitus in the Northwestern population of Iran. Iranian Red Crescent Medical Journal،Vol. 20, no. 11, pp.1-6.
https://search.emarefa.net/detail/BIM-898289
Modern Language Association (MLA)
Jalili, Ziba& Onsori, Habib. The association of C-Reactive Protein (CRP) Gene Polymorphism (+ 1059 G > C) with type 2 diabetes mellitus in the Northwestern population of Iran. Iranian Red Crescent Medical Journal Vol. 20, no. 11 (Nov. 2018), pp.1-6.
https://search.emarefa.net/detail/BIM-898289
American Medical Association (AMA)
Jalili, Ziba& Onsori, Habib. The association of C-Reactive Protein (CRP) Gene Polymorphism (+ 1059 G > C) with type 2 diabetes mellitus in the Northwestern population of Iran. Iranian Red Crescent Medical Journal. 2018. Vol. 20, no. 11, pp.1-6.
https://search.emarefa.net/detail/BIM-898289
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 5-6
Record ID
BIM-898289