Effect of aqueous extract of Agaricus bispporus on lipid profile of female albino mice treated with peroxide

Abstract EN

Agaricus bisporus is cultivated edible mushroom .

This study is made to evaluate the activity of A.

bisporus extract on lipid profile in mice treated with peroxide.

40 females albino mice were chosen and divided into 4 groups (ten mice per each group).

The first group was treated with normal saline as a control, the second group received 2ml/kg body weight of peroxide , While the third set received 2ml/kg body weight of peroxide plus 25 mg/ml A bisporus .Besides, the last fourth group received 25 mg/ml of A.

bisporus.

The Results have showed a significant increase (p≤ 0.05) in cholesterol(CH) in group 2 (250.01± 1.05)and group3 (204.25±1.80), while there was no significant decrease in CH level of group 4(170.01±2.01) as compared with control group(184.00± 1.02).

As well, there was a significant increase in Low Density Lipoprotein (LDL) in group 2 (159.23±0.9) and group 3 (158.32±2.00), while there was a significant decrease (110.95±1.3) in the level of this parameter in group 4 as compared with the control group(115.98±2.2).

Moreover, there was a significant differences in the levels High Density Lipoprotein ( HDL) ,Very Low Density Lipoprotein (VLDL) Triglyceride and in all treated groups compared with the control group