Spectrophotometric determination of ibuprofen and nystatin via ion pair complex formation using chromotrope 2R
Other Title(s)
التقدير الطيفي للإيبوبروفين و النستاتين بتكوين معقد المزدوج الأيوني باستخدام كروموتروب 2R
Joint Authors
al-Subhah, Diya Najm
Shihab, Intisar Adil
Source
al-Tarbiyah wa-al-Ilm : Majallat ilmiyah lil-Buhuth al-Ilmiyah al-Asasiyah
Issue
Vol. 28, Issue 2 (30 Jun. 2019), pp.289-299, 11 p.
Publisher
University of Mosul College of Education for Pure Science
Publication Date
2019-06-30
Country of Publication
Iraq
No. of Pages
11
Main Subjects
Abstract EN
This research paper tackles a developed method for Ibuprofen and Nystatin drugs determination both in their pure form and pharmaceutical formulations.
The proposed method is based on the formation of binary complexes (ion association complexes) between the above drugs and Chromotrope 2R (C2R) in acidic medium forming a reddish orange colours .The complexes show maximum absorption at 562 nm and 566 nm for Ibuprofen and Nystatin respectively.
The method was adhering to the Beer's law over concentration range 10-90 and 2-40 µg/ml with molar absorptivity values 1.36×103 and 7.59×103 l.
mol-1.
cm-1and average recovery 99.77% and 100.60 % for the above mentioned drugs respectively.
No observed interferences appeared from the excipients commonly existed in pharmaceuticals.
Successfully, application for both Ibuprofen and Nystatin was conducted in their pharmaceutical formulations.
American Psychological Association (APA)
Shihab, Intisar Adil& al-Subhah, Diya Najm. 2019. Spectrophotometric determination of ibuprofen and nystatin via ion pair complex formation using chromotrope 2R. al-Tarbiyah wa-al-Ilm : Majallat ilmiyah lil-Buhuth al-Ilmiyah al-Asasiyah،Vol. 28, no. 2, pp.289-299.
https://search.emarefa.net/detail/BIM-899128
Modern Language Association (MLA)
Shihab, Intisar Adil& al-Subhah, Diya Najm. Spectrophotometric determination of ibuprofen and nystatin via ion pair complex formation using chromotrope 2R. al-Tarbiyah wa-al-Ilm : Majallat ilmiyah lil-Buhuth al-Ilmiyah al-Asasiyah Vol. 28, no. 2 (2019), pp.289-299.
https://search.emarefa.net/detail/BIM-899128
American Medical Association (AMA)
Shihab, Intisar Adil& al-Subhah, Diya Najm. Spectrophotometric determination of ibuprofen and nystatin via ion pair complex formation using chromotrope 2R. al-Tarbiyah wa-al-Ilm : Majallat ilmiyah lil-Buhuth al-Ilmiyah al-Asasiyah. 2019. Vol. 28, no. 2, pp.289-299.
https://search.emarefa.net/detail/BIM-899128
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 298-299
Record ID
BIM-899128