Perineural invasion in oral squamous cell carcinoma in relation to tumor depth
Joint Authors
Rashid, Farah Sabah
Abd Allah, Bashshar Hamid
Source
Journal of Baghdad College of Dentistry
Issue
Vol. 31, Issue 2 (30 Jun. 2019), pp.1-6, 6 p.
Publisher
University of Baghdad College of Dentistry
Publication Date
2019-06-30
Country of Publication
Iraq
No. of Pages
6
Main Subjects
Topics
Abstract EN
Background: The American Joint committee on Cancer in their 8th edition staging manual regarded perineural invasion as one of the most important prognostic factors for Lip and Oral Cavity Squamous Cell Carcinoma, it also incorporated tumor depth of invasion in defining tumor size category in the new staging system.
This study was conducted to evaluate the frequency of perineural invasion in oral squamous cell carcinoma and the effect of approaching tumor depth in this process.
Materials and Methods: fifty-four formalin fixed paraffin embedded tissue blocks of radical resections of Oral Squamous Cell Carcinoma were cut and stained with Hematoxylin and Eosin stain, then evaluated for perineural invasion, with estimation of tumor depth of invasion for each case.
Results: Perineural invasion was found in twenty-two cases of the study sample.
The diameter of the largest nerve bundle that showed perineural invasion was found to have a positive significant correlation with tumor depth of invasion (p=0.025).
Perineural invasion status in terms of (present, absent) showed a significant difference with patients’ age (p=0.037), also showed a significant association with tumor site (p=0.004), however, this association was non-significant in regard to tumor grade and stage (p=0.848, p=0.520) respectively.
Conclusion: The attacking potential of preceding tumor depth and those cancers affecting young individuals may be reflected by the presence of neural infiltration by tumor cells.
Tongue resected tumors should be carefully inspected for this deceptive biological process.
American Psychological Association (APA)
Rashid, Farah Sabah& Abd Allah, Bashshar Hamid. 2019. Perineural invasion in oral squamous cell carcinoma in relation to tumor depth. Journal of Baghdad College of Dentistry،Vol. 31, no. 2, pp.1-6.
https://search.emarefa.net/detail/BIM-899499
Modern Language Association (MLA)
Rashid, Farah Sabah& Abd Allah, Bashshar Hamid. Perineural invasion in oral squamous cell carcinoma in relation to tumor depth. Journal of Baghdad College of Dentistry Vol. 31, no. 2 (Jun. 2019), pp.1-6.
https://search.emarefa.net/detail/BIM-899499
American Medical Association (AMA)
Rashid, Farah Sabah& Abd Allah, Bashshar Hamid. Perineural invasion in oral squamous cell carcinoma in relation to tumor depth. Journal of Baghdad College of Dentistry. 2019. Vol. 31, no. 2, pp.1-6.
https://search.emarefa.net/detail/BIM-899499
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 5-6
Record ID
BIM-899499