Spectrophotometric assay of salbutamol sulphate in pharmaceutical preparations by coupling with Diazotized ρ-bromoaniline

Abstract EN

In this research, salbutamol sulphate (SAS) has been determined by a simple, rapid and sensitive spectrophotometric method.

Salbutamol sulphate in this method is based on the coupling of SAS with diazotized ρ- bromoaniline reagent in alkaline medium of Triton X-100 (Tx) to form an orange azo dye which is stable and water-soluble.

The azo dye is exhibiting maximum absorption at 441 nm.

A 10 - 800 μg of SAS is obeyed of Beer's law in a final volume of 20 ml, i.e., 0.5- 40 ppm with ε, the molar absorptivity of 48558 L.mol-1.cm-1 and Sandell's sensitivity index of 0.01188 μg.cm-2.

This new method does not need solvent extraction or temperature control which is well applied to determine SAS in different types of pharmaceutical preparations.