Synthesis, characterization and antimicrobial activity study of some new substituted benzoxazole derivatives
Other Title(s)
تحضير و تشخيص مع دراسة للفعالية ضد المايكروبات لبعض مشتقات معوض البنزواوكسازول الجديدة
Author
Source
Issue
Vol. 16, Issue 3 (30 Sep. 2019), pp.616-625, 10 p.
Publisher
University of Baghdad College of Science for Women
Publication Date
2019-09-30
Country of Publication
Iraq
No. of Pages
10
Main Subjects
Topics
Abstract EN
This research included the preparation of 2-mercaptobenzoxazole (N1) by the reaction of ortho-aminophenol with carbon disulfide in an alcoholic potassium hydroxide solution.
The 2-mercapto benzoxazole (N1) was then treated with hydrazine to obtain the 2-hydrazino benzoxazole (N2).
A number of hydrazones (N3-N5) were prepared through the reaction of N2 with different benzaldehydes.
The compound (N6) was also prepared whereby the ring closing of hydrazone (N3) using chloroacetylchloride, while the compound (N7) was prepared by treating 2-hydrazino benzoxazole with acetylacetone.
When the compound (N1) was treated with formaldehyde, it afforded the compound (N8).
Also, the N9 was obtained from the reaction of N1 with chloroacetic acid in the presence of alcoholic potassium hydroxide.
The prepared compounds were characterized using physico-chemical and spectroscopic methods such as melting point, infrared spectroscopy (IR) and the proton nuclear magnetic resonance (1H-NMR).
Thereafter, some of the compounds were selected for in vitro antibacterial activity and one of these compounds showed an inhibition effect against gram positive only which is very important because it is considered as specific antibacterial drug.
American Psychological Association (APA)
al-Hiti, Numan Faruq. 2019. Synthesis, characterization and antimicrobial activity study of some new substituted benzoxazole derivatives. Baghdad Science Journal،Vol. 16, no. 3, pp.616-625.
https://search.emarefa.net/detail/BIM-899605
Modern Language Association (MLA)
al-Hiti, Numan Faruq. Synthesis, characterization and antimicrobial activity study of some new substituted benzoxazole derivatives. Baghdad Science Journal Vol. 16, no. 3 (2019), pp.616-625.
https://search.emarefa.net/detail/BIM-899605
American Medical Association (AMA)
al-Hiti, Numan Faruq. Synthesis, characterization and antimicrobial activity study of some new substituted benzoxazole derivatives. Baghdad Science Journal. 2019. Vol. 16, no. 3, pp.616-625.
https://search.emarefa.net/detail/BIM-899605
Data Type
Journal Articles
Language
English
Notes
Record ID
BIM-899605