TCR-CD3ζ gene expression profile in patients with rheumatoid arthritis and correlation with disease activity
Joint Authors
al-Nimr, Rihab A.
Abd al-Ati, Abir A.
Jamal al-Din, Marwah
Ismail, Ahmad
Source
Egyptian Rheumatology and Rehabilitation
Issue
Vol. 46, Issue 4 (31 Dec. 2019), pp.262-268, 7 p.
Publisher
The Egyptian Society for Rheumatology and Rehabilitation
Publication Date
2019-12-31
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Topics
Abstract EN
Objective To measure the T-cell receptor-CD3 zeta chain (TCR-CD3ζ) gene expression profile in a cohort of patients with rheumatoid arthritis (RA).
Patients and methods A case–control study on 150 consecutive RA patients diagnosed according to 2010 ACR/EULAR criteria and 150 matched healthy controls without a family history of RA or other autoimmune diseases.
RA patients with other autoimmune diseases, viral hepatitis B or C, malignancy or hematological disorders were excluded from the study.
All participants were subjected to history taking, clinical examination, assessment of disease activity (in RA patients) using Disease Activity Score-28 and Health Assessment Questionnaire, routine laboratory investigations, inflammatory marker levels, serological tests, as well as molecular analysis for TCR-CD3ζ mRNA expression by quantitative real-time PCR.
Results TCR-CD3ζ gene expression was significantly lower in RA cases than in controls (P<0.05).
Expression of TCR-CD3ζ has shown a significant negative correlation with RA disease duration, rheumatoid factor, and erythrocyte sedimentation rate (P<0.05) in RA cases.
The level of TCR-CD3ζ also showed a significantly less expression in patients with positive rheumatoid factor.
Conclusion Our results demonstrated a lower expression of TCR-CD3ζ in RA patients than in healthy controls.
We suggested that CD247 gene downregulation might contribute in the susceptibility to RA and help understanding the pathways responsible for deficient T-cell responses in RA patients.
American Psychological Association (APA)
Abd al-Ati, Abir A.& al-Nimr, Rihab A.& Ismail, Ahmad& Jamal al-Din, Marwah. 2019. TCR-CD3ζ gene expression profile in patients with rheumatoid arthritis and correlation with disease activity. Egyptian Rheumatology and Rehabilitation،Vol. 46, no. 4, pp.262-268.
https://search.emarefa.net/detail/BIM-899721
Modern Language Association (MLA)
Abd al-Ati, Abir A.…[et al.]. TCR-CD3ζ gene expression profile in patients with rheumatoid arthritis and correlation with disease activity. Egyptian Rheumatology and Rehabilitation Vol. 46, no. 4 (Oct. / Dec. 2019), pp.262-268.
https://search.emarefa.net/detail/BIM-899721
American Medical Association (AMA)
Abd al-Ati, Abir A.& al-Nimr, Rihab A.& Ismail, Ahmad& Jamal al-Din, Marwah. TCR-CD3ζ gene expression profile in patients with rheumatoid arthritis and correlation with disease activity. Egyptian Rheumatology and Rehabilitation. 2019. Vol. 46, no. 4, pp.262-268.
https://search.emarefa.net/detail/BIM-899721
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 267-268
Record ID
BIM-899721