TCR-CD3ζ gene expression profile in patients with rheumatoid arthritis and correlation with disease activity

Joint Authors

al-Nimr, Rihab A.
Abd al-Ati, Abir A.
Jamal al-Din, Marwah
Ismail, Ahmad

Source

Egyptian Rheumatology and Rehabilitation

Issue

Vol. 46, Issue 4 (31 Dec. 2019), pp.262-268, 7 p.

Publisher

The Egyptian Society for Rheumatology and Rehabilitation

Publication Date

2019-12-31

Country of Publication

Egypt

No. of Pages

7

Main Subjects

Medicine

Topics

Abstract EN

Objective To measure the T-cell receptor-CD3 zeta chain (TCR-CD3ζ) gene expression profile in a cohort of patients with rheumatoid arthritis (RA).

Patients and methods A case–control study on 150 consecutive RA patients diagnosed according to 2010 ACR/EULAR criteria and 150 matched healthy controls without a family history of RA or other autoimmune diseases.

RA patients with other autoimmune diseases, viral hepatitis B or C, malignancy or hematological disorders were excluded from the study.

All participants were subjected to history taking, clinical examination, assessment of disease activity (in RA patients) using Disease Activity Score-28 and Health Assessment Questionnaire, routine laboratory investigations, inflammatory marker levels, serological tests, as well as molecular analysis for TCR-CD3ζ mRNA expression by quantitative real-time PCR.

Results TCR-CD3ζ gene expression was significantly lower in RA cases than in controls (P<0.05).

Expression of TCR-CD3ζ has shown a significant negative correlation with RA disease duration, rheumatoid factor, and erythrocyte sedimentation rate (P<0.05) in RA cases.

The level of TCR-CD3ζ also showed a significantly less expression in patients with positive rheumatoid factor.

Conclusion Our results demonstrated a lower expression of TCR-CD3ζ in RA patients than in healthy controls.

We suggested that CD247 gene downregulation might contribute in the susceptibility to RA and help understanding the pathways responsible for deficient T-cell responses in RA patients.

American Psychological Association (APA)

Abd al-Ati, Abir A.& al-Nimr, Rihab A.& Ismail, Ahmad& Jamal al-Din, Marwah. 2019. TCR-CD3ζ gene expression profile in patients with rheumatoid arthritis and correlation with disease activity. Egyptian Rheumatology and Rehabilitation،Vol. 46, no. 4, pp.262-268.
https://search.emarefa.net/detail/BIM-899721

Modern Language Association (MLA)

Abd al-Ati, Abir A.…[et al.]. TCR-CD3ζ gene expression profile in patients with rheumatoid arthritis and correlation with disease activity. Egyptian Rheumatology and Rehabilitation Vol. 46, no. 4 (Oct. / Dec. 2019), pp.262-268.
https://search.emarefa.net/detail/BIM-899721

American Medical Association (AMA)

Abd al-Ati, Abir A.& al-Nimr, Rihab A.& Ismail, Ahmad& Jamal al-Din, Marwah. TCR-CD3ζ gene expression profile in patients with rheumatoid arthritis and correlation with disease activity. Egyptian Rheumatology and Rehabilitation. 2019. Vol. 46, no. 4, pp.262-268.
https://search.emarefa.net/detail/BIM-899721

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references : p. 267-268

Record ID

BIM-899721