Fas-mediated apoptosis and peripheral polyneuropathy in type 2 diabetes mellitus
Joint Authors
al-Tawwab, Sarah S.
Mujlia, Majdi H. Zikri
Abu al-Wafa, Riham A.
Abd al-Fadil, Marwah R.
Abd al-Hamid, Muwaffaq Mustafa
al-Sawi, Nuha Abd al-Halim
Source
Egyptian Rheumatology and Rehabilitation
Issue
Vol. 46, Issue 4 (31 Dec. 2019), pp.321-326, 6 p.
Publisher
The Egyptian Society for Rheumatology and Rehabilitation
Publication Date
2019-12-31
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Topics
Abstract EN
Objective To evaluate the role of soluble Fas (sFas) and soluble Fas ligand (sFasL) in the pathogenesis of distal symmetrical polyneuropathy (DSPN) in patients with type 2 diabetes mellitus, and to analyze the relationship between these apoptotic markers with clinical parameters and electrophysiologic profile of DSPN, as well as with different diabetic factors among those patients.
Patients and methods The study included 60 Egyptians with type 2 diabetes mellitus.
All patients were evaluated clinically for DSPN by using Michigan Neuropathy Screening Instrument.
Electrophysiological diagnosis of DSPN was based on the criteria suggested by the European Standardized Telematic tool to Evaluate Electrodiagnostic Methods group.
Diabetic patients were divided into two groups according to the electrophysiological findings: group A included patients with DSPN (N=42), and group B included patients without DSPN (N=18).
The severity of DSPN among group A patients was assessed clinically using Toronto Clinical Neuropathy Score and electrophysiologically by the severity score proposed by Hidasi and colleagues.
The study also included 30 healthy volunteers as a control group.
Serum levels of sFas and sFasL were assessed in all the studied groups.
Results Serum level of sFas was significantly elevated in diabetic patients with DSPN compared with diabetics without DSPN and nondiabetic control (P=0.029 and 0.000).
Receiver operating characteristic (ROC) curve analysis detected that sFas was statistically significant in discriminating between diabetic patients with DSPN from those patients without DSPN with an accuracy of 66%.
The cutoff point that has the highest sensitivity (61%) and specificity (62%) was 33.3 ng/ml.
Serum level of sFas showed a positive significant correlation with the electrophysiological severity of DSPN (P=0.020).
Serum level of sFasL did not show statistically significant difference between all the studied groups.
Conclusion Fas-mediated apoptosis has an important role in the development of diabetic DSPN and is correlated with its electrophysiological severity.
American Psychological Association (APA)
Abd al-Hamid, Muwaffaq Mustafa& al-Sawi, Nuha Abd al-Halim& Mujlia, Majdi H. Zikri& al-Tawwab, Sarah S.& Abu al-Wafa, Riham A.& Abd al-Fadil, Marwah R.. 2019. Fas-mediated apoptosis and peripheral polyneuropathy in type 2 diabetes mellitus. Egyptian Rheumatology and Rehabilitation،Vol. 46, no. 4, pp.321-326.
https://search.emarefa.net/detail/BIM-899761
Modern Language Association (MLA)
Abd al-Hamid, Muwaffaq Mustafa…[et al.]. Fas-mediated apoptosis and peripheral polyneuropathy in type 2 diabetes mellitus. Egyptian Rheumatology and Rehabilitation Vol. 46, no. 4 (Oct. / Dec. 2019), pp.321-326.
https://search.emarefa.net/detail/BIM-899761
American Medical Association (AMA)
Abd al-Hamid, Muwaffaq Mustafa& al-Sawi, Nuha Abd al-Halim& Mujlia, Majdi H. Zikri& al-Tawwab, Sarah S.& Abu al-Wafa, Riham A.& Abd al-Fadil, Marwah R.. Fas-mediated apoptosis and peripheral polyneuropathy in type 2 diabetes mellitus. Egyptian Rheumatology and Rehabilitation. 2019. Vol. 46, no. 4, pp.321-326.
https://search.emarefa.net/detail/BIM-899761
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 325-326
Record ID
BIM-899761