Spectrophotometric determination of some drugs using oxidation reduction reactions
Author
Salim, Basimah Ahmad Abd al-Hadi
Source
Ibn al-Haitham Journal for Pure and Applied Science
Issue
Vol. 32, Issue 3 (31 Dec. 2019), pp.43-55, 13 p.
Publisher
University of Baghdad College of Education for Pure Science / Ibn al-Haitham
Publication Date
2019-12-31
Country of Publication
Iraq
No. of Pages
13
Main Subjects
Topics
Abstract EN
spectrophotometric method is proposed for the determination of some drugs containing amino group such as mesalazine, metoclopramide and dopamine in pharmaceutical formulations.
It was simple, precise, accurate, rapid, and based on the oxidation of each drug with chromate as an oxidizing agent in the presence of 1N hydrochloric acid.
Then indigo carmine is reacted with residual chromate in the presence of a catalysis factor (sodium oxalate).
Increasing in absorbance's value of the color system is proportional to the amount of the three drugs which is measured at the selected wavelength of 610 nm.
The proposed method is obeying Beer's law in the ranges of (1-40, 2-44 and 2-52) ppm for the concentration of mesalazine, metoclopramide and dopamine respectively.
Molar absorptivity was 0.191×104, 0.449×104 and 0.191×104 L.mol-1.cm-1 mesalazine, metoclopramide and dopamine respectively.
While, Sandell's sensitivity index of 0.0806, 0.0667 and 0.0806 μg.cm-2 mesalazine, metoclopramide and dopamine respectively.
The proposed spectrophotometric method has a good recovery when it is applied for the determination of the three drugs in pure form and pharmaceutical doses.
American Psychological Association (APA)
Salim, Basimah Ahmad Abd al-Hadi. 2019. Spectrophotometric determination of some drugs using oxidation reduction reactions. Ibn al-Haitham Journal for Pure and Applied Science،Vol. 32, no. 3, pp.43-55.
https://search.emarefa.net/detail/BIM-899934
Modern Language Association (MLA)
Salim, Basimah Ahmad Abd al-Hadi. Spectrophotometric determination of some drugs using oxidation reduction reactions. Ibn al-Haitham Journal for Pure and Applied Science Vol. 32, no. 3 (Dec. 2019), pp.43-55.
https://search.emarefa.net/detail/BIM-899934
American Medical Association (AMA)
Salim, Basimah Ahmad Abd al-Hadi. Spectrophotometric determination of some drugs using oxidation reduction reactions. Ibn al-Haitham Journal for Pure and Applied Science. 2019. Vol. 32, no. 3, pp.43-55.
https://search.emarefa.net/detail/BIM-899934
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 52-55
Record ID
BIM-899934