Polymorphism of angiotensin type 1 receptor gene (SNP rs5186 A1166C)‎ related with hypertension patients in Baghdad

Abstract EN

This study was done to detect the contribution of at1r (A1166C) SNP rs5186 gene polymorphism in some Iraqi patients diagnosed with essential hypertension.

This study has been started from October 2017 till the end of June 2018.

Five ml of blood samples were collected from 100 subjects including 50 patients and 50 apparently healthy persons as a control group.

DNA was extracted from all samples using DNA extraction kit (gyscn, geneaid ) and PCR was performed to detect SNP (A1166C).

The results showed that AA genotype frequency was higher in healthy people (68%) than in patients (42%) with highly significant differences, and AC frequency was higher in patients (50%) than in control (30%) with highly significant differences (p<0.01).And CC genotype was only 1(2%) in control, and 4(8%) in patients.

The allele frequencies were as follow (A) allele were 0.83 in control and 0.67 in patients (P).

Furthermore the (C) allele frequency was as follow, 0.17 in control and 0.33 in patients.

We concluded from the current study that the Angiotensin type 1 Receptor (AT1R) A1166C gene polymorphism, may be associated with hypertension in some Iraqi patients .and the C allele may be considered as a risk factor for developing hypertension.