Hemostatic changes in patients with chronic renal failure

Abstract EN

Background: Renal disease results in significant disorder of hemostasis (bleeding diathesis or hypercoagulable state).

Objectives: This study is to determine the changes in some hemostasis parameters in patients with chronic renal failure and identify the effect of dialysis on these changes.

Patients and Methods: seventy five patients with end stage chronic renal failure were collected from Baghdad hospital, a full detailed history and clinical examination were performed, 50 patients were on maintenance weekly hemodialysis, and 25 patients were without dialysis.

Result: Bleeding time was significantly higher in patients with chronic renal failure who didn’t need any type of dialysis, positive D-Dimer test.

In some patients, Platelet count, prothrombin time, thrombin time, fibrinogene level, activated partial thromboplastin time; all did not reach significant level between both groups of patients.

Conclusion: hemostatic changes are not uncommon in patients with chronic renal failure, affecting the different parameter hemostasis so it should be consider in the management of these patients.