The relationship between human papilloma virus (HPV) infection and gene expression of miRNA-744, BCL-2, CASPASE-3 genes associated with cervical cancer in Iraqi patient
Joint Authors
al-Faysal, Abd al-Husayn Muwayt
Jasim, Tabarak S.
Source
Iraqi Journal of Biotechnology
Issue
Vol. 17, Issue 2 (30 Sep. 2018), pp.30-35, 6 p.
Publisher
University of Baghdad Genetic Engineering and Biotechnology for Postgraduate Studies
Publication Date
2018-09-30
Country of Publication
Iraq
No. of Pages
6
Main Subjects
Topics
Abstract EN
: Most types of HPV are harmless and some types are high risk and can cause cervical cancer or abnormal cells in the lining of the cervix that sometimes turn into cancer.
A total number of 90 subjects (70 Iraqi patients with cervical dysplasia (abnormalities) and 20 apparently healthy women) were included in this study.
The patients and healthy were aged between 25-55 years.
The molecular detection in our study showed that 30 of patients were positive to HPV and 40 patients were negative to virus compared to negative results in healthy women.
The most common genotypes is HPV-16.
Also multiple infections of HPV-HR were observed in the infected women.
The correlation between gene expression, histopathology and HPV virus showed a significant increase of folding values of the genes mi-RNA744 and caspase-3 parallel to decrease of folding value of the gene Bcl-2 which indicated that the apoptosis rate was increased with the histopathology grade where the highest level of expression of the genes was in carcinoma.
The results also revealed that mi-RNA744 could be up regulator of the gene caspase-3 and down regulator of the gene Bcl-2.
American Psychological Association (APA)
Jasim, Tabarak S.& al-Faysal, Abd al-Husayn Muwayt. 2018. The relationship between human papilloma virus (HPV) infection and gene expression of miRNA-744, BCL-2, CASPASE-3 genes associated with cervical cancer in Iraqi patient. Iraqi Journal of Biotechnology،Vol. 17, no. 2, pp.30-35.
https://search.emarefa.net/detail/BIM-900295
Modern Language Association (MLA)
Jasim, Tabarak S.& al-Faysal, Abd al-Husayn Muwayt. The relationship between human papilloma virus (HPV) infection and gene expression of miRNA-744, BCL-2, CASPASE-3 genes associated with cervical cancer in Iraqi patient. Iraqi Journal of Biotechnology Vol. 17, no. 2 (Sep. 2018), pp.30-35.
https://search.emarefa.net/detail/BIM-900295
American Medical Association (AMA)
Jasim, Tabarak S.& al-Faysal, Abd al-Husayn Muwayt. The relationship between human papilloma virus (HPV) infection and gene expression of miRNA-744, BCL-2, CASPASE-3 genes associated with cervical cancer in Iraqi patient. Iraqi Journal of Biotechnology. 2018. Vol. 17, no. 2, pp.30-35.
https://search.emarefa.net/detail/BIM-900295
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 34-35
Record ID
BIM-900295