Synthesis, characterization and anti microbial activity of some new derivatives containing imidazol moiety
Joint Authors
Abbas, Ruba Fahmi
Abd al-Abbas, Dhifaf Abd al-Azim
Alawi, Amjad Ghali
Abd al-Hasan, Nagham Majid
Muhammad, Iman Rajab
Source
Journal of Kufa for Chemical Science
Issue
Vol. 2, Issue 4 (30 Jun. 2018), pp.69-85, 17 p.
Publisher
University of Kufa Faculty of Education for Women Department of Chemistry
Publication Date
2018-06-30
Country of Publication
Iraq
No. of Pages
17
Main Subjects
Topics
Abstract EN
This paper involves synthesis some new imidazol derivatives were synthesized reaction of p-nitro Aniline with 3-chloro 2,4-pentadione with KSCN to give [1-(4-Nitro Phenyl)-2-Mercapto-4-methyl-1H-imidazol-5- yl)]-ethanone(1).
Which reaction with different aromatic aldehydes according to claisen.
Schmidt condensation to get a chalcones were reacted with hydrazine Hydrate to obtained the pyrazol derivatives and (4a-c) was synthesized by the treatment of pyrazol derivatives with benzoyl chloride in TEA.
The chalcones were cyclized with the hydroxyl amine hydro chloride to give an iso oxazole derivatives which condensed with furan-2-aldehyde to obtain compounds(6a-c).
These compounds were characterized using FTIR and 1H-NMR.
Anti microbial study in vitro screened against several bacterial by cup plate agar diffusion method and also very good antibacterial activity was observed.
American Psychological Association (APA)
Alawi, Amjad Ghali& Abd al-Hasan, Nagham Majid& Abbas, Ruba Fahmi& Muhammad, Iman Rajab& Abd al-Abbas, Dhifaf Abd al-Azim. 2018. Synthesis, characterization and anti microbial activity of some new derivatives containing imidazol moiety. Journal of Kufa for Chemical Science،Vol. 2, no. 4, pp.69-85.
https://search.emarefa.net/detail/BIM-900440
Modern Language Association (MLA)
Abbas, Ruba Fahmi…[et al.]. Synthesis, characterization and anti microbial activity of some new derivatives containing imidazol moiety. Journal of Kufa for Chemical Science Vol. 2, no. 4 (Jun. 2018), pp.69-85.
https://search.emarefa.net/detail/BIM-900440
American Medical Association (AMA)
Alawi, Amjad Ghali& Abd al-Hasan, Nagham Majid& Abbas, Ruba Fahmi& Muhammad, Iman Rajab& Abd al-Abbas, Dhifaf Abd al-Azim. Synthesis, characterization and anti microbial activity of some new derivatives containing imidazol moiety. Journal of Kufa for Chemical Science. 2018. Vol. 2, no. 4, pp.69-85.
https://search.emarefa.net/detail/BIM-900440
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 84-85
Record ID
BIM-900440