Evaluation of the role of chitosan in the immunopathology of osteomyelitis in diabetic rabbits
Other Title(s)
تقييم دور الكايتوسان في المناعة المرضية لإلتهاب العظم في الأرانب المصابة بداء السكري
Joint Authors
Maktuf, Zaynab Abd al-Karim
Ahmad, Jihad Abd al-Amir
Source
Basrah Journal of Veterinary Research
Issue
Vol. 17, Issue 2 (31 Dec. 2018), pp.51-69, 19 p.
Publisher
University of Basrah College of Veterinary Medicine
Publication Date
2018-12-31
Country of Publication
Iraq
No. of Pages
19
Main Subjects
Abstract EN
This study was conducted to investigate the beneficial effects of chitosan in the immunopathology of osteomyelitis in diabetic rabbits; therefore, the experimental design was carried out on 40 rabbits.
They were divided into 5 groups each of 8 animals, diabetes mellitus was induced in rabbits , then infected by Staphylococcus aureus and treated as following: First group (G1) was induced diabetes mellitus then immunized by whole sonicated S.
aureus antigens (WSSAG) and induced experimentally osteomyelitis.
The second group (G2) was induced diabetes mellitus, then immunized by (WSSAG) and induced experimentally osteomyelitis and fed on diet containing chitosan.
Third group (G3) was induced diabetes mellitus, and induced experimentally osteomyelitis only.
Fourth group (G4) was induction of diabetes mellitus, and induced experimentally osteomyelitis and fed on diet containing chitosan.
Fifth group (G5) was induced experimentally osteomyelitis only without diabetes mellitus induction.
Then at day 28th - 30th post immunization, skin test was performed to each of the immunized groups, and at day 30th the antibodies titer was measured by passive hemagglutination assay and phagocytic activity, then the animals were sacrificed and the treated bone taken for histopathological examination.
In the present study , a significant increase was noted in the value of skin thickness of G2 at 48 and 72 hrs PI.
A significant increase was also noted in the value of antibodies titers of G2.
We also showed a marked decrease in the t1/2 of carbon clearance of G2.
American Psychological Association (APA)
Maktuf, Zaynab Abd al-Karim& Ahmad, Jihad Abd al-Amir. 2018. Evaluation of the role of chitosan in the immunopathology of osteomyelitis in diabetic rabbits. Basrah Journal of Veterinary Research،Vol. 17, no. 2, pp.51-69.
https://search.emarefa.net/detail/BIM-900451
Modern Language Association (MLA)
Maktuf, Zaynab Abd al-Karim& Ahmad, Jihad Abd al-Amir. Evaluation of the role of chitosan in the immunopathology of osteomyelitis in diabetic rabbits. Basrah Journal of Veterinary Research Vol. 17, no. 2 (2018), pp.51-69.
https://search.emarefa.net/detail/BIM-900451
American Medical Association (AMA)
Maktuf, Zaynab Abd al-Karim& Ahmad, Jihad Abd al-Amir. Evaluation of the role of chitosan in the immunopathology of osteomyelitis in diabetic rabbits. Basrah Journal of Veterinary Research. 2018. Vol. 17, no. 2, pp.51-69.
https://search.emarefa.net/detail/BIM-900451
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 67-69
Record ID
BIM-900451