Hematological profile of rats treated with quercetin derivative against carbon tetrachloride (CCL4 )‎ toxicity

Abstract EN

The effect of quercetin derivative (1-(-2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy- 4 H –chromen-4-ylidene) thiourea coded (QTU) on the hematological profile of Wistarrats induced toxicity with carbon tetrachloride (CCl4) was investigated.

Administration intra peritoneal injection of 12.5 mg /kg and 25mg/kg of quercetin derivative (QTU) ,after four weeks of being exposure to CCl4, led to a significant decrease (p<0.05) in WBC count, with a corresponding increase on PCV and Hb.

It was also observed that the functional recovery of these blood indices is concentration dependent.

Results of this study revealed a depletion of RBC and a decrease in Packed Cell Volume (PCV) and Hemoglobin (Hb),In addition, an elevation in the levels of White Blood Cell (WBC) caused by CCl4 compared to control samples.