Effects of tadalafil and-or silymarin on gonadal function in adults male albino rats
Other Title(s)
آثار تادالافيل و-أو سيليمارين على وظيفة الغدد التناسلية في ذكور الجرذان البيضاء البالغة
Joint Authors
al-Muzayl, Muhsin Saghir Ghalib Muhsin
Ghanim, Walid Khalid
Kazim, Haytham Jawad
Source
Basrah Journal of Veterinary Research
Issue
Vol. 17, Issue 2 (31 Dec. 2018), pp.147-160, 14 p.
Publisher
University of Basrah College of Veterinary Medicine
Publication Date
2018-12-31
Country of Publication
Iraq
No. of Pages
14
Main Subjects
Abstract EN
Taldalafil is a long acting phosphodiesterase-5 inhibitor widely used in the treatment of erectile dysfunction.
The abuse of tadalafil, which is a worldwide problem, is associated with many side effects.
Sylimarin considered as a herbal drug, its active constituents are silybin, isosilybin, silydianin and silychristin.
A controversy exist with regard to the effects of tadalafil and silymarin on gonadal function in animal species.
The present study aimed to investigate the effects of tadalafil and/or sylimarin on gonadal function adult male rates.
Twenty four male rats are used in the study, they divided into 4 groups (n=6) and gavaged daily for 1 month as follows; 1-control(0.5ml distilled water), 2-tadalafil (10mg tadalafil/kg ), 3- silymarin (100 mg silymarin/ kg) and 4-tadalafil + silymarin ( 10 mg tadalafil and 100 silymarin mg/ kg).
Tadalafil significantly increases serum testosterone and decreases LH and FSH, it adversely affect the process of spermatogenesis (sperm count and percentage of motile, dead, and abnormal sperms).
While, silymarin significantly increases serum testosterone, LH and FSH and improve spermatogenesis.
Serum testosterone remains significantly higher in tadalafil+silymarin group compared with control group, while FSH and LH and parameters of spermatogenesis became insignificantly different from those in control group.
American Psychological Association (APA)
al-Muzayl, Muhsin Saghir Ghalib Muhsin& Kazim, Haytham Jawad& Ghanim, Walid Khalid. 2018. Effects of tadalafil and-or silymarin on gonadal function in adults male albino rats. Basrah Journal of Veterinary Research،Vol. 17, no. 2, pp.147-160.
https://search.emarefa.net/detail/BIM-900461
Modern Language Association (MLA)
al-Muzayl, Muhsin Saghir Ghalib Muhsin…[et al.]. Effects of tadalafil and-or silymarin on gonadal function in adults male albino rats. Basrah Journal of Veterinary Research Vol. 17, no. 2 (2018), pp.147-160.
https://search.emarefa.net/detail/BIM-900461
American Medical Association (AMA)
al-Muzayl, Muhsin Saghir Ghalib Muhsin& Kazim, Haytham Jawad& Ghanim, Walid Khalid. Effects of tadalafil and-or silymarin on gonadal function in adults male albino rats. Basrah Journal of Veterinary Research. 2018. Vol. 17, no. 2, pp.147-160.
https://search.emarefa.net/detail/BIM-900461
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 156-160
Record ID
BIM-900461