Effects of tadalafil and-or silymarin on gonadal function in adults male albino rats

Other Title(s)

آثار تادالافيل و-أو سيليمارين على وظيفة الغدد التناسلية في ذكور الجرذان البيضاء البالغة

Joint Authors

al-Muzayl, Muhsin Saghir Ghalib Muhsin
Ghanim, Walid Khalid
Kazim, Haytham Jawad

Source

Basrah Journal of Veterinary Research

Issue

Vol. 17, Issue 2 (31 Dec. 2018), pp.147-160, 14 p.

Publisher

University of Basrah College of Veterinary Medicine

Publication Date

2018-12-31

Country of Publication

Iraq

No. of Pages

14

Main Subjects

Veterinary Medicine

Abstract EN

Taldalafil is a long acting phosphodiesterase-5 inhibitor widely used in the treatment of erectile dysfunction.

The abuse of tadalafil, which is a worldwide problem, is associated with many side effects.

Sylimarin considered as a herbal drug, its active constituents are silybin, isosilybin, silydianin and silychristin.

A controversy exist with regard to the effects of tadalafil and silymarin on gonadal function in animal species.

The present study aimed to investigate the effects of tadalafil and/or sylimarin on gonadal function adult male rates.

Twenty four male rats are used in the study, they divided into 4 groups (n=6) and gavaged daily for 1 month as follows; 1-control(0.5ml distilled water), 2-tadalafil (10mg tadalafil/kg ), 3- silymarin (100 mg silymarin/ kg) and 4-tadalafil + silymarin ( 10 mg tadalafil and 100 silymarin mg/ kg).

Tadalafil significantly increases serum testosterone and decreases LH and FSH, it adversely affect the process of spermatogenesis (sperm count and percentage of motile, dead, and abnormal sperms).

While, silymarin significantly increases serum testosterone, LH and FSH and improve spermatogenesis.

Serum testosterone remains significantly higher in tadalafil+silymarin group compared with control group, while FSH and LH and parameters of spermatogenesis became insignificantly different from those in control group.

American Psychological Association (APA)

al-Muzayl, Muhsin Saghir Ghalib Muhsin& Kazim, Haytham Jawad& Ghanim, Walid Khalid. 2018. Effects of tadalafil and-or silymarin on gonadal function in adults male albino rats. Basrah Journal of Veterinary Research،Vol. 17, no. 2, pp.147-160.
https://search.emarefa.net/detail/BIM-900461

Modern Language Association (MLA)

al-Muzayl, Muhsin Saghir Ghalib Muhsin…[et al.]. Effects of tadalafil and-or silymarin on gonadal function in adults male albino rats. Basrah Journal of Veterinary Research Vol. 17, no. 2 (2018), pp.147-160.
https://search.emarefa.net/detail/BIM-900461

American Medical Association (AMA)

al-Muzayl, Muhsin Saghir Ghalib Muhsin& Kazim, Haytham Jawad& Ghanim, Walid Khalid. Effects of tadalafil and-or silymarin on gonadal function in adults male albino rats. Basrah Journal of Veterinary Research. 2018. Vol. 17, no. 2, pp.147-160.
https://search.emarefa.net/detail/BIM-900461

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references : p. 156-160

Record ID

BIM-900461