Protective effect of myrtuscommunis l.on arsenic-induced pathological changes on brain tissue of white rats

Abstract EN

The study was performed on twelve white rats of approximately of the same body weight ( 200-220 gms).

It divided equally into four groups.The 1st group was injected with (10mg/kg B.W) arsenic chloride intraperitoneally, 2nd group was injected with (10mg/kg B.W) arsenic chloride intraperitoneally and (3 mg/ml) myrtle extractL.

3rd group was normal control, rats treated orally with(3 mg/ml) myrtle extract only .4th group was injected with (0.2ml) distal water as a control group.At the end of theexperiment, the animals were sacrificed,and small specimens(2cm³) were taken from brain to histopathology preparation.

The microscopic examination of histopathological sections of thebrain of the1st group was showed severe pathological changes characterizedby an area of degeneration,vacuolation of microglia &pyknosis of neuron also there are edema&hemorrhage.On the other hand, the 2ndgroup showed less pathological changes compared by 1st group which characterized by less gliosis, less vaculation of microglia with few number of astrocyte.The neuron showed normal.while, the 3rd and 4th groups showed normal neurons, microglial, and astrocyte