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Comparative study of the therapeutic potential of mesenchymal stem cells derived from adipose tissue and bone marrow on acute myocardial infarction model
Joint Authors
Umar, Amirah M.
Milis, Anisah E.
Arafah, Samiyah A.
Zahran, Nuha M.
Muhanna, Radawi A.
Source
Issue
Vol. 34, Issue 6 (30 Nov. 2019), pp.534-543, 10 p.
Publisher
Publication Date
2019-11-30
Country of Publication
Oman
No. of Pages
10
Main Subjects
Topics
Abstract EN
Objectives Stem cell therapy is a promising approach in the treatment of acute myocardial infarction (AMI).
Mesenchymal stem cells (MSC) from bone marrow (BM-MSC) and adipose tissue (AT-MSC) are attractive and feasible for preclinical and clinical trials.
In this study, we compared the therapeutic potential of BM-MSC and AT-MSC in repairing the hearts of rats with isoproterenol (ISO)-induced AMI.
Methods Forty-two female rats were assigned into two groups; the optimization and the experimental group.
The optimization groups were further subdivided into control group and the AMI induced group (using ISO).
The experimental group was subdivided into AMI+cell-free media injected in the tail vein, AMI+BM-MSC, and AMI+AT-MSC groups treated with the intravenous injection of their respective cell types.
Twenty-eight days after induction, electrocardiogram (ECG) was performed, and heart tissue samples were collected for histological assessment and cells tracing.
Results MSC therapy repaired cardiac functions shown by the restoration of ST segment, QT and QRS intervals in the ECG when compared to the AMI group.
Infarct area was significantly decreased, and cardiac tissue regeneration signs were shown on histopathological examination.
Conclusions Both MSC sources proved to be equally efficient in the assessed parameters.
American Psychological Association (APA)
Umar, Amirah M.& Milis, Anisah E.& Arafah, Samiyah A.& Zahran, Nuha M.& Muhanna, Radawi A.. 2019. Comparative study of the therapeutic potential of mesenchymal stem cells derived from adipose tissue and bone marrow on acute myocardial infarction model. Oman Medical Journal،Vol. 34, no. 6, pp.534-543.
https://search.emarefa.net/detail/BIM-900508
Modern Language Association (MLA)
Umar, Amirah M.…[et al.]. Comparative study of the therapeutic potential of mesenchymal stem cells derived from adipose tissue and bone marrow on acute myocardial infarction model. Oman Medical Journal Vol. 34, no. 6 (Nov. 2019), pp.534-543.
https://search.emarefa.net/detail/BIM-900508
American Medical Association (AMA)
Umar, Amirah M.& Milis, Anisah E.& Arafah, Samiyah A.& Zahran, Nuha M.& Muhanna, Radawi A.. Comparative study of the therapeutic potential of mesenchymal stem cells derived from adipose tissue and bone marrow on acute myocardial infarction model. Oman Medical Journal. 2019. Vol. 34, no. 6, pp.534-543.
https://search.emarefa.net/detail/BIM-900508
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 542-543
Record ID
BIM-900508