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The role of vitamin c on the structural changes of male albino rats kidney induced by tramadol
Other Title(s)
تأثير الترامادول على التركيب النسيجي على كلى ذكور الجرذان البالغة و الدور الوقائي المحتمل لفيتامين سي
Joint Authors
Ahmad, Rana Mustafa
al-Azzawi, Nadwa Subhi
al-Hubayti, Abd al-Jabbar Yasin Muhammad
Source
Annals of the College of Medicine Mosul
Issue
Vol. 41, Issue 1 (30 Jun. 2019), pp.57-62, 6 p.
Publisher
University of Mosul College of Medicine-Mosul
Publication Date
2019-06-30
Country of Publication
Iraq
No. of Pages
6
Main Subjects
Topics
Abstract EN
Aim of study: The aim of this work is to detect the toxic effects of tramadol on the microscopic structure of the kidneys of adult male albino rats, and the possible protective role of vitamin C against these toxic effects.
Method: Thirty adult albino rats are used in this study.
The animals were divided into three equal groups: Group A (control group): Animals were injected daily with normal saline for 4 weeks.
Group B (Tramadol treated group) (TGI): Animals were injected daily with tramadol in a dose of 50mg/kg b.wt for 4 weeks.
Group C (group treated with tramadol+vitamin C) (TGII): Animals were injected with vitamin C in a dose 100mg/Kg/b.wt half hour prior to tramadol injection in the same dose as in group B for 4 weeks.
The injection was given intraperitoneally for all animals.
At the end of the experiments, the rats were anaesthetized by ether, then killed.
After that kidneys removed, fixed in formaldehyde and processed for microscopic examination.
Result: Tramadol causes shrinkage of renal glomeruli with widening of bowman's space.
Renal tubules showed hydropic degeneration and vacuolization of their epithelial cells.
Infiltration of mononuclear cells along with Hyaline cast is seen within the degenerated tubules.
Giving vitamin C prior to tramadol injection results in improvement in the microscopical structure of kidney mainly in glomeruli and tubules.
Conclusion: Using tramadol caused damage to renal glomeruli and tubules in renal cortex.
The addition of vitamin C partially improved the histological structure of kidney.
American Psychological Association (APA)
Ahmad, Rana Mustafa& al-Hubayti, Abd al-Jabbar Yasin Muhammad& al-Azzawi, Nadwa Subhi. 2019. The role of vitamin c on the structural changes of male albino rats kidney induced by tramadol. Annals of the College of Medicine Mosul،Vol. 41, no. 1, pp.57-62.
https://search.emarefa.net/detail/BIM-900844
Modern Language Association (MLA)
Ahmad, Rana Mustafa…[et al.]. The role of vitamin c on the structural changes of male albino rats kidney induced by tramadol. Annals of the College of Medicine Mosul Vol. 41, no. 1 (Jun. 2019), pp.57-62.
https://search.emarefa.net/detail/BIM-900844
American Medical Association (AMA)
Ahmad, Rana Mustafa& al-Hubayti, Abd al-Jabbar Yasin Muhammad& al-Azzawi, Nadwa Subhi. The role of vitamin c on the structural changes of male albino rats kidney induced by tramadol. Annals of the College of Medicine Mosul. 2019. Vol. 41, no. 1, pp.57-62.
https://search.emarefa.net/detail/BIM-900844
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 62
Record ID
BIM-900844