Glycosylation gap in gallstone patients

Abstract EN

Background: Gall stones are one of the commonest biliary diseases.

Interest in the formation and clinical management of the disease dates back to ancient times.

Gall stones continue to be one of the major health problems in the world today, although the exact number of patients is unknown, because there are no signs and symptoms related to the disease when there are no complications.

The majority of the patients are diagnosed incidentally.

However, some patients come with acute complication of gall stones.

Gall stones are classified into; cholesterol gall stones, pigment gall stones, and mixed gall stones.

However, all stones even pure cholesterol gall stones usually contain bilirubin (conjugated and unconjugated bilirubin) and cholesterol.

Aim: To determine the changes in glycosylation gap and glycation profile and the relation of this change to the changes in age and BMI on the measured parameters.

Patients and methods: Serum samples were collected from 40 individuals included in this work.

They are divided into 2 groups.

The first group included 20 apparently healthy individuals (10 males and 10 females).

The second group included 20 individuals (5 males and 15 females) with Gall stone diagnosed in out-patient Clinic at Al-Jamhoory General Hospital and Neinawa private Hospital.

Gall stone patients with metabolic diseases, infections and other inflammatory diseases were excluded.

Results: The study demonstrated a significant elevation in serum glucose, mean blood glucose, serum fructosamin, measured and predicated HbAc1 in GS patients in comparison with controls.

Regarding the relation between age and measured parameters, the study showed a non-significant correlation between age and measured parameters in the control group, while in GS group there were a significant correlation (r = 0.05) between ages and predicted HbAc1 and BMI (p ≤ 0.03).

Regarding the relation between BMI and measured parameters, the study showed a significant correlation between measured parameters and BMI in GS individuals, while in control group only serum glucose and MBG in control group (r = 0.01) (p ≤ 0.01) with MBI.

Conclusion: The study shows that there is a significant change in glycosylation gap and glycation profile in gall stone patients.