Serum Corin and Furin levels among hypertensive male adult patients in middle Governorate-Gaza strip

Other Title(s)

مستوى إنزيمات الكورين و الفيورين لدى الذكور البالغين من مرضى ارتفاع ضغط الدم في المحافظة الوسطى-قطاع غزة

Dissertant

Mazid, Hana Salman Rajab

Thesis advisor

al-Zabut, Bakr Mahmud

University

Islamic University

Faculty

Faculty of Science

Department

Department of Biological Science

University Country

Palestine (Gaza Strip)

Degree

Master

Degree Date

2017

English Abstract

Background: Hypertension is a major global public health issue that causes cardiovascular disease (CVD), stork and other diseases that lead to death.

Natriuretic peptides (NPs) are significant for balance of salt-water and blood pressure.

Corin and furin are major cardiac enzymes that control of blood pressure (BP) by activating NPs, so regulating many cardiac function and hypertension.

Objective: To assess serum corin and furin levels and some biochemical parameters among newly diagnosed primary hypertensive patients in Gaza Strip.

Materials and Methods: Data were obtained from biochemical analysis and face to face questionnaire interview.

Forty five blood samples from hypertensive patients and 45 from healthy persons were collected.

ELISA techniques were used to investigate serum corin and furin levels.

Enzymatic and colorimetric techniques were used to investigate urea, creatinine, total protein, albumin, potassium and lipid profile.

All groups were matched for each other's in age, sex and residence.

Results: The average age of the healthy individuals were (43.5±8.4) years whilst that of hypertensive patients were (44.2±7.7) years, (P >0.05).

The Physical activity and diet were associated with hypertension (P=0.023, 0.008) respectively.

About half of patients were hypertensive since ≤5 years.

The main self-reported complications were retinopathy, cardiovascular diseases and recurrent infection.

Body mass index, weight, diastolic & systolic BP were positively related with hypertension (P >0.05).

Serum urea, creatinine, potassium (K) and albumin were higher in hypertensive (40.1±9.5 vs 31.6±6.0, 1.0±0.2 vs 0.90±0.10 mg/dl, 4.6±0.5 vs 4.3±0.4 mmol/l and 4.3±0.4 vs 4.0±0.3 g/dl, % differences=23.7, 10.5, 6.7 and 7.2, respectively and P<0.05).

Triglycerides, cholesterol, low & high-density lipoprotein cholesterol were significantly elevated in hypertensive (195.6±58.3, 196.8±46.4, 196.8±46.4 and 47.5±4.0 mg/dl) than controls (166.2±63.0, 170.4±29.3, 170.4±29.3 and 45.8±3.5 mg/dl) with % differences of 14.4, 16.3, 3.6 & 18.8 % and P = 0.002, P = 0.024, P = 0.038 & P = 0.009, respectively).

Corin in serum was significantly increased in controls (61.1±81.2 ng/ml, t=-4.096 and P = 0.000) compared to cases.

In contrast, serum furin was scientifically increased in cases (717.3±759.4 pg/ml, t=2.143 and P = 0.035).

There was statistically significant association between serum corin and smoking (t=2.360, P = 0.020), and between serum furin and education among the study population (t=3.456, P = 0.020).

For the study population, there were negative correlation between corin and furin in controls (P = 0.010, r = -0.381) & cases (P < 0.001, r = -0.676).

In contrast, serum corin and furin levels not correlated with SBP (mmHg), DBP (mmHg), age, weight, height, BMI, duration of hypertension, age at diagnosis of hypertension and most biochemical studied parameters among the study population.

Main Subjects

Biology

No. of Pages

84

Table of Contents

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Language

English

Data Type

Arab Theses

Record ID

BIM-900921