![](/images/graphics-bg.png)
In Vivo evaluation of the novel nanocomposite porous 3D scaffold in a rabbit model : hematology and biochemistry analysis
Other Title(s)
تقييم فيفو للسقالات الثلاثية الأبعاد المسامية المركبة النانوية الأصيلة في نموذج الأرنب : تحليل الدم و الكيمياء الحيوية
Joint Authors
Bint Abd al-Razzaq, Intan Samihah
Yusuf, Luqman Muhammad
Mahmud, Zayd Khidr
Zakariyya, Muhammad Zuki Abu Bakr
Abu Bakr, Adamu Abd
Bin Ab Latip, Muhammad Qaium
Mahmud, Saffanah Khidr
Source
Iraqi Journal of Veterinary Sciences
Issue
Vol. 32, Issue 2 (31 Dec. 2018), pp.219-230, 12 p.
Publisher
University of Mosul College of Veterinary Medicine
Publication Date
2018-12-31
Country of Publication
Iraq
No. of Pages
12
Main Subjects
Abstract EN
Issues of safety are very crucial with biomaterials and medical devices.
Sixteen male New Zealand White rabbits equally into four groups : Group A, rabbits had part of their radial bone (2 cm, mid shaft) and left empty as a control.
Group B, rabbits were implanted with scaffold 5211.
Group C, rabbits were implanted with scaffold 5211GTA+Alginate.
Group D, rabbits were implanted with 5211PLA.
All scaffolds were prepared by freeze-drying method.
Blood samples were collected at day 0 and 1st, 2nd, 3rd, 4th and 8th week after implantation.
The blood examination included complete hemogram and certain serum biochemical parameters.
The results showed that there was no significant difference (P>0.05) among each treatment group in comparison with control group (day 0).
However, red blood cells, hemoglobin, packed cell volume, mean corpuscular hemoglobin concentration, monocyte, plasma protein, inorganic phosphate, sodium, chloride and urea were significantly increased (P < 0.05) among treatment groups at week 8.
An abnormal architecture of viscera was observed in all animals, thus indicating a form of toxicity related to the degrading scaffold materials.
The severity of histopathological lesions in viscera was not coated polymers dependent nor development materials.
In conclusion, implantation of 5211 scaffold with or without coated framework has a significant impact on histopathological and certain hematological and biochemical parameters.
American Psychological Association (APA)
Mahmud, Saffanah Khidr& Zakariyya, Muhammad Zuki Abu Bakr& Bint Abd al-Razzaq, Intan Samihah& Yusuf, Luqman Muhammad& Abu Bakr, Adamu Abd& Mahmud, Zayd Khidr…[et al.]. 2018. In Vivo evaluation of the novel nanocomposite porous 3D scaffold in a rabbit model : hematology and biochemistry analysis. Iraqi Journal of Veterinary Sciences،Vol. 32, no. 2, pp.219-230.
https://search.emarefa.net/detail/BIM-900952
Modern Language Association (MLA)
Mahmud, Saffanah Khidr…[et al.]. In Vivo evaluation of the novel nanocomposite porous 3D scaffold in a rabbit model : hematology and biochemistry analysis. Iraqi Journal of Veterinary Sciences Vol. 32, no. 2 (2018), pp.219-230.
https://search.emarefa.net/detail/BIM-900952
American Medical Association (AMA)
Mahmud, Saffanah Khidr& Zakariyya, Muhammad Zuki Abu Bakr& Bint Abd al-Razzaq, Intan Samihah& Yusuf, Luqman Muhammad& Abu Bakr, Adamu Abd& Mahmud, Zayd Khidr…[et al.]. In Vivo evaluation of the novel nanocomposite porous 3D scaffold in a rabbit model : hematology and biochemistry analysis. Iraqi Journal of Veterinary Sciences. 2018. Vol. 32, no. 2, pp.219-230.
https://search.emarefa.net/detail/BIM-900952
Data Type
Journal Articles
Language
English
Notes
Text in English ; abstracts in English and Arabic.
Record ID
BIM-900952