Spectrophotometric determination of hydroxyurea in pharmaceutical preparations
Other Title(s)
التقدير الطيفي للهيدروكسي يوريا في المستحضرات الصيدلانية
Author
Source
Issue
Vol. 27, Issue 4 (31 Aug. 2018), pp.29-36, 8 p.
Publisher
University of Mosul College of Science
Publication Date
2018-08-31
Country of Publication
Iraq
No. of Pages
8
Main Subjects
Pharmacy, Health & Medical Sciences
Chemistry
Abstract EN
A simple spectrophotometric method for the determination of hydroxyurea has been developed.
The method is based on the oxidation of hydroxyurea with iron(III) in acidic medium, and the liberated iron(II) reacts with 1,10-phenanthroline to form the orange-red chelate which has a maximum absorption at 510 nm.
Beer's law is obeyed over the concentration range 5-160 μg of hydroxyurea in a final volume of 25 ml, with a molar absorptivity of 2.36×104 l.mol-1.cm-1 and Sandell's sensitivity index of 0.0032 μg.cm-2, a relative error of -2.4 to +1.6% and a relative standard deviation of ±0.32 to ±1.5%, depending on the concentration level.
Interferences due to excipients have been examined.
The proposed method has been applied successfully to the determination of hydroxyurea in pharmaceutical formulations (capsules).
American Psychological Association (APA)
al-Samman, Firyal M.. 2018. Spectrophotometric determination of hydroxyurea in pharmaceutical preparations. Rafidain Journal of Science،Vol. 27, no. 4, pp.29-36.
https://search.emarefa.net/detail/BIM-901232
Modern Language Association (MLA)
al-Samman, Firyal M.. Spectrophotometric determination of hydroxyurea in pharmaceutical preparations. Rafidain Journal of Science Vol. 27, no. 4 (2018), pp.29-36.
https://search.emarefa.net/detail/BIM-901232
American Medical Association (AMA)
al-Samman, Firyal M.. Spectrophotometric determination of hydroxyurea in pharmaceutical preparations. Rafidain Journal of Science. 2018. Vol. 27, no. 4, pp.29-36.
https://search.emarefa.net/detail/BIM-901232
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 36
Record ID
BIM-901232