TH17 AND tregulatory cells in type2 diabetic nephropathy

Joint Authors

Zuhayri, Muna Kamil
Amin, Malak Nabil
Uqbah, Ashraf Mahmud
Isa, Abir Abd al-Hamid
Abu Talib, Huda Muhammad Ali
Ibrahim, Muhammad Ashraf

Source

Journal of the Egyptian Society of Parasitology

Issue

Vol. 48, Issue 3 (31 Dec. 2018), pp.605-613, 9 p.

Publisher

The Egyptian Society of Parasitology

Publication Date

2018-12-31

Country of Publication

Egypt

No. of Pages

9

Main Subjects

Medicine

Topics

Abstract EN

Type 2 diabetes mellitus and diabetic nephrophathy considered to be an inflammatory process in which immune cells involved in its development and progression apart from traditional metabolic and hemodynamic risk factors.

This study was designed to determine the balance between T helper 17 and regulatory T cells in Type 2 diabetic patients having diabetic nephropathy in relation to type 2 diabetic patients without renal involvement and healthy individuals.

This study included 3 groups; diabetic2 nephrophathy patients (on basis of proteinuria and reduced GFR), diabetic patients (ADA, 2015) and healthy controls of the same age and sex Detection of T regs and Th 17 cell were evaluated; T regs expressing CD4 & CD 25 while Th 17 cells expressing CD4 and CD161 was done by standard 2-color flow cytometry and Th17/Treg cells ratio was calculated.

The results revealed that there was higher mean Th17 and Th17/Treg cells ratio among type 2 diabetic nephropathy patients compared to other two groups.

There was lower mean Treg cells among type 2 diabetic nephropathy patients compared to other two groups with very high statistically significant differences.

Also, there was higher mean Th17 and Th17/Treg cells ratio among type 2 diabetic patients compared to healthy individuals with very statistically significant differences that there was a strong positive correlation between BUN, serum creatinine, proteinuria and the grade of nephrropathic affection by the ultrasound from one side and Th17 and Th17/T reg cells ratio on the other side.

But this correlation was strongly negative with T reg cells.

American Psychological Association (APA)

Amin, Malak Nabil& Uqbah, Ashraf Mahmud& Isa, Abir Abd al-Hamid& Ibrahim, Muhammad Ashraf& Zuhayri, Muna Kamil& Abu Talib, Huda Muhammad Ali. 2018. TH17 AND tregulatory cells in type2 diabetic nephropathy. Journal of the Egyptian Society of Parasitology،Vol. 48, no. 3, pp.605-613.
https://search.emarefa.net/detail/BIM-901274

Modern Language Association (MLA)

Amin, Malak Nabil…[et al.]. TH17 AND tregulatory cells in type2 diabetic nephropathy. Journal of the Egyptian Society of Parasitology Vol. 48, no. 3 (Dec. 2018), pp.605-613.
https://search.emarefa.net/detail/BIM-901274

American Medical Association (AMA)

Amin, Malak Nabil& Uqbah, Ashraf Mahmud& Isa, Abir Abd al-Hamid& Ibrahim, Muhammad Ashraf& Zuhayri, Muna Kamil& Abu Talib, Huda Muhammad Ali. TH17 AND tregulatory cells in type2 diabetic nephropathy. Journal of the Egyptian Society of Parasitology. 2018. Vol. 48, no. 3, pp.605-613.
https://search.emarefa.net/detail/BIM-901274

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references : p. 611-613

Record ID

BIM-901274