In vitro scolicidal effect of bee venom on Echinococcus granulosus protoscolices
Author
Source
Journal of the Egyptian Society of Parasitology
Issue
Vol. 48, Issue 3 (31 Dec. 2018), pp.689-697, 9 p.
Publisher
The Egyptian Society of Parasitology
Publication Date
2018-12-31
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Topics
Abstract EN
Hydatid disease has significant economic and health impacts in many parts of the world including Egypt and the Middle East.
Surgery remains the most efficient treatment, however, dissemination of protoscolex-rich fluid during surgery is a major cause of recurrence.
Instillation of a scolicidal agent into hydatid cysts is the most commonly employed measure to prevent this complication.
To date, various scolicidal agents have been tried with varying success.
Many of these scolicidal agents may cause unacceptable side effects.
The present study investigated the scolicidal effect of bee venom (BV) on Echinococcus granulosus protoscolices.
Protoscolices were incubated with 50ppm and 100ppm BV for 30 minutes and scolicidal effect was assessed by motility, eosin exclusion test, morphological and ultrastructural alterations by light microscopy and Transmission Electron Microscopy (TEM).
Apoptosis was determined by caspase-3 immunohistochemistry.
Protoscolices incubated with 50ppm BV showed decreased viability by eosin exclusion test while those incubated with 100ppm BV showed a 100% death rate.
BV caused distinct alterations in the morphology of protoscolices by both light microscopy and TEM and the expression of caspase-3 in protoscolices incubated with BV was significantly high.
The results of the present study suggested that BV can be a very promising scolicidal agent and further studies on its effects and safety in experimental animals are recommended.
American Psychological Association (APA)
Tawfiq, Raniya Ayman. 2018. In vitro scolicidal effect of bee venom on Echinococcus granulosus protoscolices. Journal of the Egyptian Society of Parasitology،Vol. 48, no. 3, pp.689-697.
https://search.emarefa.net/detail/BIM-901293
Modern Language Association (MLA)
Tawfiq, Raniya Ayman. In vitro scolicidal effect of bee venom on Echinococcus granulosus protoscolices. Journal of the Egyptian Society of Parasitology Vol. 48, no. 3 (Dec. 2018), pp.689-697.
https://search.emarefa.net/detail/BIM-901293
American Medical Association (AMA)
Tawfiq, Raniya Ayman. In vitro scolicidal effect of bee venom on Echinococcus granulosus protoscolices. Journal of the Egyptian Society of Parasitology. 2018. Vol. 48, no. 3, pp.689-697.
https://search.emarefa.net/detail/BIM-901293
Data Type
Journal Articles
Language
English
Notes
Includes appendix : p. 695-697
Record ID
BIM-901293