Diffuse large b-cell lymphomaof the lung in pregnancy : a case report

Abstract EN

Primary lung lymphoma (PLL) or pulmonary diffuse large B-cell lymphoma (DLBCL) is a rare entity.

There is an increase incidence of DLBCL in patients with autoimmune disorders and recurrent or chronic bacterial infection.

However, the cause is more complex and involves certain genetic factors for its development.

Having lymphoma diagnosed during pregnancy is uncommon, and relatively little information has been available about the management and outcome of lymphoma in pregnant women.

Primary pulmonary DLBCL during pregnancy is not even reported in the English medical literature.We are reporting the case of a 34 y/o lady who was diagnosed with DLBCL of the lung during the 19th week of her intrauterine pregnancy.

She was treated with R-CHOP combination chemotherapy regimen (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone) and received a total of six cycles before her delivery.

Because of the early presentation during the second trimester, she received most of the planned chemotherapy course during the pregnancy.

Follow-up of the mother showed major improvement and serial monitoring of the baby showed no developmental delays or physical abnormalities.

At delivery the baby had neither side effects from chemotherapy nor any treatment related complications or developmental defects.

FDG staging after delivery confirmed the primary pulmonary nature of the disease.

Pulmonary DLBCL may present during pregnancy and poly-chemotherapy treatments should be considered as therapeutic options in such complex scenarios.