The effects of dapagliflozin on serum electrolytes concentration in adult male rats
Other Title(s)
تأثير ديباكليفوزون على تركيز الشوارد في مصن الدم على ذكور الجرذ البالغة
Joint Authors
Ghanim, Walid Khalid
al-Muzayal, Muhsin Saghir Ghalib
al-Shawi, Nada Naji
Source
Kufa Journal for Veterinary Medical Sciences
Issue
Vol. 9, Issue 2 (31 Dec. 2018), pp.55-61, 7 p.
Publisher
University of Kufa Faculty of Veterinary Medicine
Publication Date
2018-12-31
Country of Publication
Iraq
No. of Pages
7
Main Subjects
Abstract EN
Hyperkalemia hazard is increased in diabetes, especially in patients with renal disease or those receiving angiotensin-converting enzyme (ACE) medications, angiotensin receptor blockers (ARBs) or potassium-sparing diuretics.
Also, other diuretics can increase hypokalemia danger.
Recently, We assessed the effects of dapagliflozin in ameliorate the serum calcium, sodium, potassium( Ca+2, Na+2, K+ ) and uric acid concentration in adults male rats.
In this study were erolled 18 adult male rats randomly assigned to three groups(n=6) as following: control group (I) 0.5 ml/kg B.W of normal saline.
Group II and III receive orally by gavage for 30 days 0.53 mg/kg and 1.06 mg/kg B.W of dapagliflozin.
The end of experiment the blood were collected for measuring the following parameter: blood glucose, Ca+2, Na+2, K+ ) , and uric acid concentration.
The results of the present study revealed the following: there was significant (P≤0.05) increase in body weight, K + , Ca+2 and uric acid concentration of treated II, and III groups compared with control.
On the other hand, there was significant (P≤0.05) decrease in Na+2 concentration of treated compared with control.
The experiment was concluded that Dapagliflozin in dose dependent pattern produce significant effects in reduction body weight in II and III groups compared with I group, furthermore, shows that changes in serum concentrations of potassium, calcium and uric acid in treated groups compared to normal where as no effects on sodium concentration was found.
Also there is no differences in blood glucose concentration in treated group compared to normal, rather than hypoglycemic and all groups are normal groups
American Psychological Association (APA)
al-Muzayal, Muhsin Saghir Ghalib& al-Shawi, Nada Naji& Ghanim, Walid Khalid. 2018. The effects of dapagliflozin on serum electrolytes concentration in adult male rats. Kufa Journal for Veterinary Medical Sciences،Vol. 9, no. 2, pp.55-61.
https://search.emarefa.net/detail/BIM-901311
Modern Language Association (MLA)
al-Muzayal, Muhsin Saghir Ghalib…[et al.]. The effects of dapagliflozin on serum electrolytes concentration in adult male rats. Kufa Journal for Veterinary Medical Sciences Vol. 9, no. 2 (2018), pp.55-61.
https://search.emarefa.net/detail/BIM-901311
American Medical Association (AMA)
al-Muzayal, Muhsin Saghir Ghalib& al-Shawi, Nada Naji& Ghanim, Walid Khalid. The effects of dapagliflozin on serum electrolytes concentration in adult male rats. Kufa Journal for Veterinary Medical Sciences. 2018. Vol. 9, no. 2, pp.55-61.
https://search.emarefa.net/detail/BIM-901311
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 60-61
Record ID
BIM-901311