Effects of sodium glucose cotransporter-2 inhibitors on serum uric acid in type 2 diabetes mellitus : a systematic review with an indirect comparison meta-analysis
Joint Authors
Xin, Yakai
Li, Yanle
Ma, Yujin
Jiang, Hongwei
Guo, Yu
Li, Liping
Source
Saudi Journal of Biological Sciences
Issue
Vol. 26, Issue 2 (28 Feb. 2019), pp.421-426, 6 p.
Publisher
Publication Date
2019-02-28
Country of Publication
Saudi Arabia
No. of Pages
6
Main Subjects
Topics
Abstract EN
To describe the effects of sodium-glucose co-transporter 2 (SGLT2) inhibitors on serum uric acid (SUA) in patients with type 2 diabetes mellitus (T2DM).
PubMed, EMBASE, and CENTRAL were searched for randomized controlled trials of SGLT2 inhibitors in patients with T2DM up to Aug 10, 2017, without language or date restrictions.
Thirty-one studies totaling 13,650 patients were included.
SGLT2 inhibitors significantly decreased SUA levels compared with placebo, canagliflozin WMD –37.02 lmol/L, 95% CI [–38.41, –35.63], dapagliflozin WMD –38.05 lmol/L, 95% CI [–44.47, –31.62], empagliflozin WMD – 42.07 lmol/L, 95% CI [–46.27, –37.86].
The drug class effect of SUA reduction suggesting SGLT2 inhibitors might be beneficial for diabetic patients with hyperuricemia.
American Psychological Association (APA)
Xin, Yakai& Guo, Yu& Li, Yanle& Ma, Yujin& Li, Liping& Jiang, Hongwei. 2019. Effects of sodium glucose cotransporter-2 inhibitors on serum uric acid in type 2 diabetes mellitus : a systematic review with an indirect comparison meta-analysis. Saudi Journal of Biological Sciences،Vol. 26, no. 2, pp.421-426.
https://search.emarefa.net/detail/BIM-901429
Modern Language Association (MLA)
Xin, Yakai…[et al.]. Effects of sodium glucose cotransporter-2 inhibitors on serum uric acid in type 2 diabetes mellitus : a systematic review with an indirect comparison meta-analysis. Saudi Journal of Biological Sciences Vol. 26, no. 2 (Feb. 2019), pp.421-426.
https://search.emarefa.net/detail/BIM-901429
American Medical Association (AMA)
Xin, Yakai& Guo, Yu& Li, Yanle& Ma, Yujin& Li, Liping& Jiang, Hongwei. Effects of sodium glucose cotransporter-2 inhibitors on serum uric acid in type 2 diabetes mellitus : a systematic review with an indirect comparison meta-analysis. Saudi Journal of Biological Sciences. 2019. Vol. 26, no. 2, pp.421-426.
https://search.emarefa.net/detail/BIM-901429
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 114-116
Record ID
BIM-901429