Therapeutic effect of nigella sativa and ivermectin versus albendazole on experimental trichinellosis in mice
Joint Authors
al-Shafii, Mahmud A.
Muhammad, Samirah Mutawalli
Nada, Suad Mahdi
Muadh, Huwayda S. F.
al-Ghandur, Asma M. Faruq
Ibrahim, Najwa
Source
Journal of the Egyptian Society of Parasitology
Issue
Vol. 48, Issue 1 (30 Apr. 2018), pp.85-92, 8 p.
Publisher
The Egyptian Society of Parasitology
Publication Date
2018-04-30
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Pharmacy, Health & Medical Sciences
Abstract EN
Anthelminthics are used for trichinellosis elimination in intestine and encysted larvae in muscles.
This study evaluated the effects of Nigella sativa, ivermectin versus albendazole on experimental trichinellosis.
One hundred and twenty mice were orally infected with 200 larvae of T.
spiralis/ mouse.
Drugs were tested against mature worms in the small intestine at 7 days post infection (dpi) and encysted larvae at 35 dpi.
Parasitological assessment by counting of adult worms and encysted larvae was done as well as histopathologically.
Biochemical measuring of serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), total protein, albumin, globulin, and urea, creatinine and creatinine phosphokinase (CPK) values was done.
High significant reductions in mean adult count was detected in N.
sativa prophylactic, ivermectin and albendazole treated mice with efficacies of 45.9 %, 97.4 % & 83.6 % respectively with mild significant reduction in N.
sativa treated mice with percent reduction 26.5 %.
At 35 dpi, there was high significant reduction in mean larval count as compared to the control infected mice with reduction of 43.7 %, 65.3 %, 99.4 % & 80 % in N.
sativa prophylactic, N.
sativa treated, ivermectin and albendazole respectively.
Reduction of AST, ALT, urea, creatinine and CPK levels but total proteins increased in all treated mice compared to corresponding infected non-treated ones.
Ivermectin gave the best results and continued for treating T.
spiralis.
American Psychological Association (APA)
Nada, Suad Mahdi& Muhammad, Samirah Mutawalli& Muadh, Huwayda S. F.& al-Shafii, Mahmud A.& al-Ghandur, Asma M. Faruq& Ibrahim, Najwa. 2018. Therapeutic effect of nigella sativa and ivermectin versus albendazole on experimental trichinellosis in mice. Journal of the Egyptian Society of Parasitology،Vol. 48, no. 1, pp.85-92.
https://search.emarefa.net/detail/BIM-901583
Modern Language Association (MLA)
Nada, Suad Mahdi…[et al.]. Therapeutic effect of nigella sativa and ivermectin versus albendazole on experimental trichinellosis in mice. Journal of the Egyptian Society of Parasitology Vol. 48, no. 1 (Apr. 2018), pp.85-92.
https://search.emarefa.net/detail/BIM-901583
American Medical Association (AMA)
Nada, Suad Mahdi& Muhammad, Samirah Mutawalli& Muadh, Huwayda S. F.& al-Shafii, Mahmud A.& al-Ghandur, Asma M. Faruq& Ibrahim, Najwa. Therapeutic effect of nigella sativa and ivermectin versus albendazole on experimental trichinellosis in mice. Journal of the Egyptian Society of Parasitology. 2018. Vol. 48, no. 1, pp.85-92.
https://search.emarefa.net/detail/BIM-901583
Data Type
Journal Articles
Language
English
Notes
Includes appendices : p. 91-92
Record ID
BIM-901583