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The adjuvant effect of allopurinol with valsartan on the treatment of essential hypertension
Other Title(s)
التأثير المساند لعقار الالوبيورينول مع الفالسارتان في علاج ارتفاع ضغط الدم الشرياني
Author
Source
Annals of the College of Medicine Mosul
Issue
Vol. 40, Issue 1 (30 Jun. 2018), pp.36-40, 5 p.
Publisher
University of Mosul College of Medicine-Mosul
Publication Date
2018-06-30
Country of Publication
Iraq
No. of Pages
5
Main Subjects
Pharmacy, Health & Medical Sciences
Abstract EN
Background: Hyperuricemia is thought to contribute to development of hypertension, an elevation of uric acid in hypertension could be a consequence of reduced renal function, or elevated renal vascular resistance.
Objective: This paper aims to evaluate the adjuvant effect of allopurinol on blood pressure in newly diagnosed essential hypertensive patients with hyperuricemia.
Design: Double-blind randomized controlled clinical trial.
Patients and methods: Sixty newly diagnosed essential hypertensive patients with hyperuricemia in private clinic were enrolled in the study.
They were randomly divided into two equal groups, group 1 was put on valsartan and allopurinol therapy, and group 2 was given valsartan and placebo therapy.
Both groups were followed for four weeks duration.
Blood pressure and serum uric acid levels were measured in both groups, before and after therapy.
Results: The systolic and diastolic blood pressures showed a significant reduction in group 1 with a mean difference of -24.20 ± 2.00 mmHg, for systolic blood pressure and -16.93 ± 4.73 mmHg for diastolic blood pressure.
The reduction in serum uric acid was -3.25 ± 0.18, while the patients group that received valsartan and placebo did not show the same improvement.
Conclusion: The administration of allopurinol had beneficial effect on blood pressure, and can be used as adjunctive therapy for patients with hypertension, particularly if they have coexistent hyperuricemia.
American Psychological Association (APA)
Husayn, Fakhir Yusuf. 2018. The adjuvant effect of allopurinol with valsartan on the treatment of essential hypertension. Annals of the College of Medicine Mosul،Vol. 40, no. 1, pp.36-40.
https://search.emarefa.net/detail/BIM-901588
Modern Language Association (MLA)
Husayn, Fakhir Yusuf. The adjuvant effect of allopurinol with valsartan on the treatment of essential hypertension. Annals of the College of Medicine Mosul Vol. 40, no. 1 (Jun. 2018), pp.36-40.
https://search.emarefa.net/detail/BIM-901588
American Medical Association (AMA)
Husayn, Fakhir Yusuf. The adjuvant effect of allopurinol with valsartan on the treatment of essential hypertension. Annals of the College of Medicine Mosul. 2018. Vol. 40, no. 1, pp.36-40.
https://search.emarefa.net/detail/BIM-901588
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 39-40
Record ID
BIM-901588