The adjuvant effect of allopurinol with valsartan on the treatment of essential hypertension

Other Title(s)

التأثير المساند لعقار الالوبيورينول مع الفالسارتان في علاج ارتفاع ضغط الدم الشرياني

Author

Husayn, Fakhir Yusuf

Source

Annals of the College of Medicine Mosul

Issue

Vol. 40, Issue 1 (30 Jun. 2018), pp.36-40, 5 p.

Publisher

University of Mosul College of Medicine-Mosul

Publication Date

2018-06-30

Country of Publication

Iraq

No. of Pages

5

Main Subjects

Pharmacy, Health & Medical Sciences

Abstract EN

Background: Hyperuricemia is thought to contribute to development of hypertension, an elevation of uric acid in hypertension could be a consequence of reduced renal function, or elevated renal vascular resistance.

Objective: This paper aims to evaluate the adjuvant effect of allopurinol on blood pressure in newly diagnosed essential hypertensive patients with hyperuricemia.

Design: Double-blind randomized controlled clinical trial.

Patients and methods: Sixty newly diagnosed essential hypertensive patients with hyperuricemia in private clinic were enrolled in the study.

They were randomly divided into two equal groups, group 1 was put on valsartan and allopurinol therapy, and group 2 was given valsartan and placebo therapy.

Both groups were followed for four weeks duration.

Blood pressure and serum uric acid levels were measured in both groups, before and after therapy.

Results: The systolic and diastolic blood pressures showed a significant reduction in group 1 with a mean difference of -24.20 ± 2.00 mmHg, for systolic blood pressure and -16.93 ± 4.73 mmHg for diastolic blood pressure.

The reduction in serum uric acid was -3.25 ± 0.18, while the patients group that received valsartan and placebo did not show the same improvement.

Conclusion: The administration of allopurinol had beneficial effect on blood pressure, and can be used as adjunctive therapy for patients with hypertension, particularly if they have coexistent hyperuricemia.

American Psychological Association (APA)

Husayn, Fakhir Yusuf. 2018. The adjuvant effect of allopurinol with valsartan on the treatment of essential hypertension. Annals of the College of Medicine Mosul،Vol. 40, no. 1, pp.36-40.
https://search.emarefa.net/detail/BIM-901588

Modern Language Association (MLA)

Husayn, Fakhir Yusuf. The adjuvant effect of allopurinol with valsartan on the treatment of essential hypertension. Annals of the College of Medicine Mosul Vol. 40, no. 1 (Jun. 2018), pp.36-40.
https://search.emarefa.net/detail/BIM-901588

American Medical Association (AMA)

Husayn, Fakhir Yusuf. The adjuvant effect of allopurinol with valsartan on the treatment of essential hypertension. Annals of the College of Medicine Mosul. 2018. Vol. 40, no. 1, pp.36-40.
https://search.emarefa.net/detail/BIM-901588

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references : p. 39-40

Record ID

BIM-901588