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Therapeutic efficacy of a cysteine proteases inhibitor (phenyl vinyl sulfone) either alone or combined with nigella sativa on experimental cryptosporidiosis
Joint Authors
Zaki, Wafa M.
al-Amir, Yasamin O.
Source
Journal of the Egyptian Society of Parasitology
Issue
Vol. 48, Issue 1 (30 Apr. 2018), pp.165-174, 10 p.
Publisher
The Egyptian Society of Parasitology
Publication Date
2018-04-30
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The present study evaluated the efficacy of a cysteine protease inhibitor (PVS) either alone or combined with Nigella sativa in treatment of cryptosporidiosis in immunosuppressed mice.
Seventy two mice were divided equally into eight groups: a normal control group (G1).
Other received dexamethasone to induce immunosuppression (G2) acted as a dexamethasone immunosuppressed control.
Six immunosuppressed groups were inoculated with infective dose of Cryptosporidum oocycts: (G3) infected control, (G4 and G5) treated with PVS alone in a dose of 50mg/kg and 100mg / kg respectively, (G6 and G7) treated with same dose of PVS and combined with NS 500mg/kg, and (G8) was treated with Paromomycin 250mg / kg.
Oocysts shedding were monitored from 2nd to 24th day post-infection.
After mice scarification, blood was assessed for hepatorenal drug toxicity.
Sections of ileum were subjected to histopathological examination.
Mice treated with PVS 100mg/kg combined with NS showed marked improvement with highest significant efficacy (P ≤0.01) diminished oocyst shedding in G6 and G7 by 91% & 94 % respectively, versus its efficacy when given alone in G4 and G5 by 83 % and 87 % respectively or when compared with paromomycin effect in G8 (81%).
PVS in different doses showed no toxic effect on hepatorenal parameters.
American Psychological Association (APA)
Zaki, Wafa M.& al-Amir, Yasamin O.. 2018. Therapeutic efficacy of a cysteine proteases inhibitor (phenyl vinyl sulfone) either alone or combined with nigella sativa on experimental cryptosporidiosis. Journal of the Egyptian Society of Parasitology،Vol. 48, no. 1, pp.165-174.
https://search.emarefa.net/detail/BIM-901620
Modern Language Association (MLA)
Zaki, Wafa M.& al-Amir, Yasamin O.. Therapeutic efficacy of a cysteine proteases inhibitor (phenyl vinyl sulfone) either alone or combined with nigella sativa on experimental cryptosporidiosis. Journal of the Egyptian Society of Parasitology Vol. 48, no. 1 (Apr. 2018), pp.165-174.
https://search.emarefa.net/detail/BIM-901620
American Medical Association (AMA)
Zaki, Wafa M.& al-Amir, Yasamin O.. Therapeutic efficacy of a cysteine proteases inhibitor (phenyl vinyl sulfone) either alone or combined with nigella sativa on experimental cryptosporidiosis. Journal of the Egyptian Society of Parasitology. 2018. Vol. 48, no. 1, pp.165-174.
https://search.emarefa.net/detail/BIM-901620
Data Type
Journal Articles
Language
English
Notes
Includes appendix : p. 173-174
Record ID
BIM-901620