Assessment of the effector antibodies against Schistosoma mansoni and their impact on Mefloquine efficacy

Abstract EN

Host immune response against Schistosoma mansoni is a major contributor in the process of resistance or susceptibility to re-infection, as well as the therapeutic response towards different antischistosomal drugs.

This study evaluated the role of IgG &IgG4 as immune-logical marker of cure and their effect on anti-schistosomal mefloquine efficacy.

Sixty Swiss albino mice were infected with Schistosoma cercaria and divided into four groups; non-infected, infected not treated, infected treated with praziquantel and infected treated with mefloquine.

The effect of drugs was assessed parasitologically using Kato-Katz technique and immunologically by measuring the serum level of anti-Schistosoma IgG and IgG4 subclass.

The results showed 83.5 % significant egg count reduction in MFQ-treated infected group.

Also, serum anti-soluble egg antigen (SEA) total IgG & IgG4 subclass levels in MFQ treated group were significantly different from infected control group & PZQ-treated infected group.