Carotid intima-media thickness assessment in obese patients with chronic renal failure

Abstract EN

Background/Aim Measurement of carotid artery intima–media thickness (CIMT) is reliable for early detection of atherosclerosis, one of obesity’s complications, which is a leading cause of mortality among patients with end-stage renal disease.

The study aimed to evaluate CIMT in relation to obesity, chronic renal failure (CRF) and both, for the early prevention of cardiovascular problems.

Patients and methods This cross-sectional study included 118 adult individuals of both sexes, aged 30–60 years.

Patients with CRF were gathered from the renal dialysis unit of King Fahd Hospital-Kasr El Einy Hospital, and the obese without CRF from the ‘Management of Visceral obesity Unit’, in ‘Medical Excellence Research Center (MERC)’, National Research Centre, during the period spanning from June 2015 to April 2016.They were grouped into three groups: a case group, which included 45 obese individuals with CRF, and two control groups: one comprised 39 nonobese patients with CRF and the other group comprised 34 obese patients without CRF.

Anthropometric assessment, lipid profile, and ultrasound measurement of CIMT were performed for each patient.

Results CIMT was greater in all groups than the normal range (0.06–0.08 cm), particularly in the obese group without renal failure.

CIMT had a highly significant correlation with waist circumference and insignificant correlation with BMI and lipid profile in different groups.

Conclusion The increase in CIMT was related to obesity and renal failure, but it was more prominent with obesity.

CIMT had highly significant correlation with central obesity in cases wherein obesity and renal failure were coexisting together and insignificant correlation with lipid profile.