Expression of estrogen receptors in epithelial ovarian carcinoma
Joint Authors
Talat, Sahar M.
Sharaf, Hafizah A.
Abd al-Al, Wafa E.
Haridi, Amal A.
Bakir, Rufandah M.
al-Sharqawi, Suniya L.
Source
Journal of the Arab Society for Medical Research
Issue
Vol. 13, Issue 1 (30 Jun. 2018), pp.71-78, 8 p.
Publisher
Arab Society for Medical Research
Publication Date
2018-06-30
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background/aim Epithelial ovarian cancer accounts for ∼3% of female cancers.
Steroid hormones such as estrogen and progesterone are thought to play an important role in the process of carcinogenesis of ovarian tumors.
There are two subtypes of the nuclear estrogen receptor (ER-α and ER-β) encoded by separate genes.
This work aimed to evaluate the expression pattern of ER-α and ER-β in epithelial ovarian carcinoma and their correlation with tumor histopathological parameters and proliferating cell nuclear antigen expression as a proliferation marker.
Materials and methods A total of 50 cases of epithelial ovarian carcinoma were included in this study.
All cases were female patients who underwent oophorectomies or subtotal or total hysterectomies with oophorectomies.
Surgical specimens were sent to Pathology Department at Kasr El-Aini hospitals and to private laboratories.
The cases were graded and staged according to WHO systems.
The cases were stained by hemotoxylin and eosin for histopathological grading, and they were immunohistochemically stained for ER-α, ER-β, and proliferating cell nuclear antigen using streptavidin–biotin technique.
Results In this study, 56% of cases were positively stained for ER-α.
It is significantly correlated with both of the tumor histological type and proliferative state of the tumors.
There was a significant inverse correlation between ER-α expression and the tumor histological grade.
Approximately 62% of cases were positively stained for ER-β.
There was a significant inverse correlation between ER-β positivity and both of the tumor stage and proliferative state of ovarian carcinoma cases.
Conclusion The loss of ER-β, not ER-α, expression in ovarian tumors may be a feature of malignant transformation suggesting its potential role as tumor suppressor gene.
Determination of ER subtypes may improve response to hormonal therapy using a selective ER modulator in selected cases of ovarian carcinoma.
American Psychological Association (APA)
al-Sharqawi, Suniya L.& Abd al-Al, Wafa E.& Talat, Sahar M.& Sharaf, Hafizah A.& Haridi, Amal A.& Bakir, Rufandah M.. 2018. Expression of estrogen receptors in epithelial ovarian carcinoma. Journal of the Arab Society for Medical Research،Vol. 13, no. 1, pp.71-78.
https://search.emarefa.net/detail/BIM-902218
Modern Language Association (MLA)
al-Sharqawi, Suniya L.…[et al.]. Expression of estrogen receptors in epithelial ovarian carcinoma. Journal of the Arab Society for Medical Research Vol. 13, no. 1 (Jan. / Jun. 2018), pp.71-78.
https://search.emarefa.net/detail/BIM-902218
American Medical Association (AMA)
al-Sharqawi, Suniya L.& Abd al-Al, Wafa E.& Talat, Sahar M.& Sharaf, Hafizah A.& Haridi, Amal A.& Bakir, Rufandah M.. Expression of estrogen receptors in epithelial ovarian carcinoma. Journal of the Arab Society for Medical Research. 2018. Vol. 13, no. 1, pp.71-78.
https://search.emarefa.net/detail/BIM-902218
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 77-78
Record ID
BIM-902218