The endoplasmic reticulum stress response in disease pathogenesis and pathophysiology
Joint Authors
Manalo, Rafael Vincent M.
Madina, Paul Mark B.
Source
The Egyptian Journal of Medical Human Genetics
Issue
Vol. 19, Issue 2 (30 Apr. 2018), pp.59-68, 10 p.
Publisher
Egyptian Society of Human Genetics
Publication Date
2018-04-30
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The minute experience of disease progression happens in the cell.
Whereas recent researches have focused separately on disease, molecular mechanisms reveal the coincidence of pathways that provide guided benefit to biomedicine.
Interestingly, taken-for-granted mechanisms like endoplasmic reticulum (ER) quality control or ion exchange and cell polarity indeed play major roles in epidemiologically relevant problems like viral infection, tumorigenesis and other chronic disorders.
The ER synthesizes proteins destined for the nucleus and Golgi, as well as cell-surface receptors needed for cell-to-cell communication.
This is therefore the target of viral infection in making the cell susceptible to receptor-mediated invasion, and is usually affected in tumor cells to promote cell insensitivity.
Any aberrations therefore, such as protein unfolding, are acted upon by molecular chaperones and prevented from leaving the ER.
These proteins are essential for cell survival, and intuitively the ER must activate stress responses to evade immediate cell dysfunction as the cell processes lag behind.
This review will discuss mainly the ER and its role in the pathogenesis and pathophysiology of epidemiologically-relevant diseases, as well as updates on mechanisms related to the ER stress response.
American Psychological Association (APA)
Manalo, Rafael Vincent M.& Madina, Paul Mark B.. 2018. The endoplasmic reticulum stress response in disease pathogenesis and pathophysiology. The Egyptian Journal of Medical Human Genetics،Vol. 19, no. 2, pp.59-68.
https://search.emarefa.net/detail/BIM-902281
Modern Language Association (MLA)
Manalo, Rafael Vincent M.& Madina, Paul Mark B.. The endoplasmic reticulum stress response in disease pathogenesis and pathophysiology. The Egyptian Journal of Medical Human Genetics Vol. 19, no. 2 (Apr. 2018), pp.59-68.
https://search.emarefa.net/detail/BIM-902281
American Medical Association (AMA)
Manalo, Rafael Vincent M.& Madina, Paul Mark B.. The endoplasmic reticulum stress response in disease pathogenesis and pathophysiology. The Egyptian Journal of Medical Human Genetics. 2018. Vol. 19, no. 2, pp.59-68.
https://search.emarefa.net/detail/BIM-902281
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 67-68
Record ID
BIM-902281